<p>In the development of floating offshore wind power, the interference from the wake of adjacent wind turbines severely restricts the overall efficiency of the wind farm. To reveal the mechanism and propose mitigation strategies, this paper uses computational fluid dynamics methods, combined with wind tunnel experiments, to systematically analyze the effects of different spacings (4–9D) and yaw angles (0° to 30°) on the aerodynamic performance and wake evolution of tandem floating wind turbines. The results show that when the spacing increases from 4 to 7D, the total power only increases by 10.5%, and further increasing to 9D, the increase reaches 37.26%. The power gradually recovers as the spacing increases; when the yaw angle increases from 0° to 30°, the upstream power continuously decreases, the downstream power gradually recovers, and the total power shows a nonlinear change of first increasing and then decreasing. The optimal yaw angle is approximately 20°, which is 3.16% higher than without yawing. The analysis of speed loss and vorticity indicates that increasing the spacing can weaken the tip vortex and accelerate the recovery of the wake, and moderate yawing can effectively deflect the core of the wake and reduce the downstream speed loss. This research provides a theoretical basis for optimizing the layout and coordinated control of floating wind turbine systems.</p>