<p>The present article examines the irreversible mechanisms and thermodynamic impacts on chemically reactive Maxwell hybrid nanofluid flow with viscous dissipation and entropy generation. Incorporated Brownian motion and thermophoresis are used to enhance the heat and mass transfer efficiency. Authors noticed that there is dearth of analysis on Maxwell fluids with the circumstance of activation energy, porous media, joule heating, thermophoresis and Brownian diffusion with heat transfer and entropy generation and utilized the research gap. Present research aids in optimizing thermal management and reaction kinetics in complex fluid systems. Al₂O₃ and SiO₂ nanoparticles mixed in base fluid SA to create hybrid nanofluid are considered. Governing nonlinear PDEs are formulated to ODEs by utilizing the similarity conversions and calculated by using numerical technique. Outcomes of the present study reveals that enhancing the MHD and porous media reduces the momentum of the fluid, raising the thermal radiation enhances the temperature, rising the Schmidt number and chemical reaction decays the concentration, enhancing the thermal radiation parameter increases both entropy generation and Bejan number, and increasing the Brownian motion parameter increases the entropy generation. Present work has many useful applications in cooling systems for electronics, power plants, and engines and also has significant applications in drug delivery systems, microfluidic devices, and energy-efficient manufacturing processes, optimizing heat transfer and reaction kinetics in complex fluid systems.</p>