<p>Water insufficiency is regarded as one of the most significant worldwide issues in the coming decade. Accordingly, seawater desalination processes can be considered as important freshwater production resources. For sustainable development, these processes should be energetically, economically, and environmentally evaluated. This paper investigates the integration of hydrate-based desalination process and liquefied natural gas regasification via energy, exergy, exergoeconomic, and exergoenvironmental analyses. In this integrated system, about 705.8 m³/h freshwater is produced while more than 200 kg/h liquefied natural gas is regasified. The specific energy consumption and water recovery of presented desalination system are 0.36 kW/m³ and 60.83%, respectively. The results of exergy analysis show that the exergy efficiency and the total destruction rate are 70.18% and 37,146.87 kW, respectively. Heat exchangers and separators and tees have the greatest and the lowest contributions in exergy destruction. Additionally, due to the exergoeconomic analysis, the exergoeconomic factors of heat exchanger H-4 and CR-1 are the greatest and the lowest values among the devices of hydrate-based desalination subsystem, respectively. Moreover, the coolant heat exchanger H-1 and separator S-2 possess the highest and the lowest values of relative cost differences, respectively. Furthermore, the exergoenvironmental assessment indicates that, seawater feed stream exchanger and LNG pump have the highest and the least exergoenvironmental factors. Also, the maximum and the minimum relative exergoenvironmental impact differences are represented by seawater feed stream heat exchanger and separator S-2.</p>