Synthesis of Amide Derivatives of Pyrimidine-Triazolo[1,5-a]pyridin-7-yl) Thiazoles: In Vitro Anticancer Evaluation and In Silico Molecular Binding Studies
摘要
A new series of pyrimidine-triazolo[1,5-a]pyridin-7-yl)thiazole derivatives (21a–j) were designed, synthesized and evaluated in vitro for their cytotoxicity against MCF-7, A2780, A549, and Colo-205 cell lines by using of MTT method with etoposide as standard medical drug. Among them, one compound 21a showed remarkable anticancer activity (MCF-7 = 0.01 ± 0.007 µM and A549 = 0.05 ± 0.006 µM). Molecular docking simulations were utilized to validate these activities and further demonstrated that these compounds demonstrated improved interaction energy and profile.