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Background and objective <p>Intracranial aneurysms in the internal carotid artery (ICA) pose significant clinical risk, particularly in the presence of abnormal hemodynamics exacerbated by arterial dilation. Flow-diverting stents offer a promising endovascular solution, yet their efficacy depends strongly on the interaction between device geometry and local blood flow dynamics.</p> Methods <p>This study employs a patient-specific computational fluid dynamics (CFD) framework to assess the hemodynamic effects of two braided stent models-standard and dense-implanted in an aneurysmal ICA. A high-fidelity immersed boundary method (IBM) is implemented to embed the stent geometry within the fluid domain without requiring mesh conformity. Simulations were performed under physiologically realistic pulsatile conditions using a non-Newtonian blood rheology model. Comparative analyses were conducted against a baseline (no-stent) model to evaluate spatial and temporal patterns of wall shear stress (WSS), time-averaged WSS (TAWSS), oscillatory shear index (OSI), and intra-aneurysmal velocity fields.</p> Results <p>Results reveal that the standard and dense stents reduced peak area-averaged WSS on the aneurysm wall by approximately 64% and 78%, respectively, compared to the no-stent model. The dense stent further achieved near-complete suppression of OSI, indicating a more stable hemodynamic environment.</p> Conclusion <p>These findings suggest that increasing stent mesh density enhances flow diversion and may improve long-term therapeutic outcomes in ICA aneurysm management.</p> Graphical abstract <p></p>

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Patient-specific hemodynamic assessment of cerebral aneurysms treated with braided stents using immersed boundary method: computational fluid dynamics study

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Ihab Omar,
  • Nashmi H. Alrasheedi,
  • As’ad Alizadeh,
  • Abdellatif M. Sadeq,
  • Ashraf Abed Hussein,
  • Husam Rajab,
  • Narinderjit Singh Sawaran Singh,
  • Walid Aich

摘要

Background and objective

Intracranial aneurysms in the internal carotid artery (ICA) pose significant clinical risk, particularly in the presence of abnormal hemodynamics exacerbated by arterial dilation. Flow-diverting stents offer a promising endovascular solution, yet their efficacy depends strongly on the interaction between device geometry and local blood flow dynamics.

Methods

This study employs a patient-specific computational fluid dynamics (CFD) framework to assess the hemodynamic effects of two braided stent models-standard and dense-implanted in an aneurysmal ICA. A high-fidelity immersed boundary method (IBM) is implemented to embed the stent geometry within the fluid domain without requiring mesh conformity. Simulations were performed under physiologically realistic pulsatile conditions using a non-Newtonian blood rheology model. Comparative analyses were conducted against a baseline (no-stent) model to evaluate spatial and temporal patterns of wall shear stress (WSS), time-averaged WSS (TAWSS), oscillatory shear index (OSI), and intra-aneurysmal velocity fields.

Results

Results reveal that the standard and dense stents reduced peak area-averaged WSS on the aneurysm wall by approximately 64% and 78%, respectively, compared to the no-stent model. The dense stent further achieved near-complete suppression of OSI, indicating a more stable hemodynamic environment.

Conclusion

These findings suggest that increasing stent mesh density enhances flow diversion and may improve long-term therapeutic outcomes in ICA aneurysm management.

Graphical abstract