<p>Triple-negative breast cancer (TNBC) constitutes 15–17% of all breast cancer cases. The absence of molecular targets restricts targeted therapy options for TNBC. Despite the availability of conventional chemotherapy, high recurrence rates and metastasis remain the primary challenges in current disease management. Nearly 46% of TNBC cases are metastasized to distant organs, which decreases the overall survival of TNBC patients. Therefore, identifying disease-specific markers, their mechanisms in metastasis, and their therapeutic potential could aid in developing better treatment options for patients. Long non-coding RNAs (lncRNAs), a subset of non-coding RNAs (&gt; 200 nucleotides), exhibit significant function in gene expression regulation and tumorigenesis. LncRNAs play a significant role in TNBC metastasis through diverse mechanisms. LncRNAs such as H19, MALAT1, and others contribute to TNBC chemotherapy resistance, invasion, migration, relapse, and immune suppression. Furthermore, the molecular interactions among lncRNAs, miRNAs, and mRNAs collectively drive key hallmarks of metastatic progression, specifically in TNBC. To provide a comprehensive understanding of these mechanisms, this review highlights the biogenesis, classification, and physiological functions of lncRNAs, along with an overview of the metastatic cascade. Specifically, it emphasizes the regulatory axes of lncRNAs with miRNAs and mRNAs in driving metastatic progression, and explores their emerging role as promising biomarkers for diagnosis and targeted therapy. Expanding the understanding of lncRNA-mediated regulatory interactions could pave the way for the identification of novel biomarkers and the development of more effective therapeutic strategies to enhance TNBC diagnosis, prognosis, and treatment outcomes.</p> Graphical abstract <p></p>