<p>Steel wire suspenders of suspension bridges, particularly in anchorage segments, are vulnerable to fatigue damage caused by the combined effects of tension and bending loads from the traffic action. This issue may be exacerbated in novel suspension bridge systems, such as the main-cable-looped suspension bridge. In this system, the main cable originates from one anchorage, loops around the opposite anchorage, and returns to its original anchorage, intensifying the potential for tension-bending coupled fatigue in steel wire suspenders. This study outlines a methodology to evaluate the tension-bending coupled fatigue life of steel wire suspenders subjected to random traffic flow. The daily random traffic flow was simulated using the Monte Carlo method based on actual traffic data collected from a weigh-in-motion (WIM) system. The time histories of tension and bending fatigue loads acting on suspenders were numerically analyzed. Subsequently, axial stress time histories and fatigue stress spectra were determined. A linear elastic fracture mechanics (LEFM) approach was developed to evaluate the tension-bending coupled fatigue life of steel wire suspenders. The methodology was implemented to analyze fatigue loads and the corresponding fatigue life of suspenders in a main-cable-looped suspension bridge. The results showed that under daily random traffic conditions, the range of tension fatigue load increases from both ends of the main girder toward the mid-span, while the range of bending fatigue load decreases with increasing suspender length. The maximum tension fatigue load range is 118.5 kN, and the maximum bending fatigue load range is 0.577°. The tension-bending coupled fatigue life of steel wire suspenders increases with the suspender length. The shortest suspender, with a minimum fatigue life of 13.1&#xa0;years, may not meet the normal design life expectancy.</p>