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Introduction <p>Chinese middle-aged and elderly (≥45&#xa0;years old) liver disease patients have a high diabetes mellitus (DM) incidence with gender differences. Identify the optimal obesity and blood lipid-related predictors of DM in such patients by sex.</p> Methods <p>Using China Health and Retirement Longitudinal Study (CHARLS) 2011–2020 data, we explored DM predictors by sex, evaluating with receiver operating characteristic (ROC), area under curve (AUC), etc., to calculate odds ratio (OR) and 95% confidence interval (CI) after confounder adjustment.</p> Results <p>Many indexes were significant (<i>P</i> &lt; 0.05). Obesity and lipid-related indexes had certain discrimination (AUC &gt; 0.5), with the triglyceride-glucose (TyG) index performing best (AUC = 0.78). The visceral adiposity index (VAI) (OR = 1.08, 95%CI = 1.04–1.12) and the triglyceride-glucose-body mass index (TyG-BMI) (OR = 1.14, 95%CI = 1.06–1.22) promoted DM in male patients, while VAI (OR = 1.12, 95%CI = 1.08–1.16) and the triglyceride-glucose-waist circumference (TyG-WC) (OR = 1.15, 95%CI = 1.09–1.21) did so in female patients.</p> Conclusion <p>TyG-BMI and TyG-WC are the best DM predictors for male and female liver disease patients, respectively. VAI also has predictive value for DM prevention.</p>

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Optimal obesity and lipid-related predictors of diabetes mellitus in middle-aged and elderly patients with liver disease in China: a CHARLS cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Yang Wu,
  • Tian Li,
  • Yanan Zhang,
  • Chujiang Wu,
  • Xiaofeng Zheng,
  • Jiucong Zhang,
  • Bing Liang

摘要

Introduction

Chinese middle-aged and elderly (≥45 years old) liver disease patients have a high diabetes mellitus (DM) incidence with gender differences. Identify the optimal obesity and blood lipid-related predictors of DM in such patients by sex.

Methods

Using China Health and Retirement Longitudinal Study (CHARLS) 2011–2020 data, we explored DM predictors by sex, evaluating with receiver operating characteristic (ROC), area under curve (AUC), etc., to calculate odds ratio (OR) and 95% confidence interval (CI) after confounder adjustment.

Results

Many indexes were significant (P < 0.05). Obesity and lipid-related indexes had certain discrimination (AUC > 0.5), with the triglyceride-glucose (TyG) index performing best (AUC = 0.78). The visceral adiposity index (VAI) (OR = 1.08, 95%CI = 1.04–1.12) and the triglyceride-glucose-body mass index (TyG-BMI) (OR = 1.14, 95%CI = 1.06–1.22) promoted DM in male patients, while VAI (OR = 1.12, 95%CI = 1.08–1.16) and the triglyceride-glucose-waist circumference (TyG-WC) (OR = 1.15, 95%CI = 1.09–1.21) did so in female patients.

Conclusion

TyG-BMI and TyG-WC are the best DM predictors for male and female liver disease patients, respectively. VAI also has predictive value for DM prevention.