Scholarlink

Background <p>The impact of intermittently scanned continuous glucose monitoring (isCGM) on quality of life (QoL) for overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes (HbA1c ≤ 7.0%) remains unclear.</p> Methods <p>In this secondary analysis of our pilot weight-loss RCT, 40 overweight individuals (BMI, ≥ 25&#xa0;kg/m<sup>2</sup>) were randomized to isCGM (isCGM plus diet-and-exercise therapy) or control (diet-and-exercise therapy alone) groups. QoL was assessed with the SF-36 questionnaire over a 6-month intervention.</p> Results <p>After exclusion of participants with missing data or who withdrew consent, 17 individuals in the isCGM group (median [interquartile range] age, 51.0 [47.0–62.5] years; BMI, 35.0 [32.2–39.0] kg/m<sup>2</sup>) and 16 individuals in the control group (age, 51.0 [41.8–65.0] years; BMI, 29.4 [25.3–35.8] kg/m<sup>2</sup>) were analyzed. No significant differences in QoL changes over the intervention period were observed between the two groups. Within the isCGM group, the Mental Component Summary (MCS) score improved significantly (from 44.8 to 48.4, <i>P</i> &lt; 0.05), whereas the Role/Social Component Summary score declined significantly (from 52.2 to 44.8, <i>P</i> &lt; 0.05). Scan frequency correlated positively with baseline Vitality, Mental Health, and MCS scores. Changes in time above range and standard deviation for sensor glucose were negatively correlated with changes in the General Health score.</p> Conclusion <p>isCGM did not improve QoL scores relative to the control group for overweight individuals with IGT or mild diabetes. Within-group analysis suggested that isCGM improved mental QoL but lowered perceived social QoL. Tailored support addressing psychological and social needs may maximise isCGM benefits.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of isCGM on quality of life in overweight individuals with impaired glucose tolerance or mild diabetes: secondary analysis of a pilot randomized controlled study

  • 期刊论文

  • 发表日期：

    2025年7月23日

查看全文
  • Seiji Nishikage,
  • Yushi Hirota,
  • Yasushi Nakagawa,
  • Mei Nakatsuji,
  • Shuichiro Saito,
  • Kai Yoshimura,
  • Mariko Ueda,
  • Akane Yamamoto,
  • Tomofumi Takayoshi,
  • Atsuko Matsuoka,
  • Michiko Takahashi,
  • Akihiko Takeda,
  • Kazuki Yokota,
  • Tomoaki Nakamura,
  • Kazuhiko Sakaguchi,
  • Wataru Ogawa

摘要

Background

The impact of intermittently scanned continuous glucose monitoring (isCGM) on quality of life (QoL) for overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes (HbA1c ≤ 7.0%) remains unclear.

Methods

In this secondary analysis of our pilot weight-loss RCT, 40 overweight individuals (BMI, ≥ 25 kg/m2) were randomized to isCGM (isCGM plus diet-and-exercise therapy) or control (diet-and-exercise therapy alone) groups. QoL was assessed with the SF-36 questionnaire over a 6-month intervention.

Results

After exclusion of participants with missing data or who withdrew consent, 17 individuals in the isCGM group (median [interquartile range] age, 51.0 [47.0–62.5] years; BMI, 35.0 [32.2–39.0] kg/m2) and 16 individuals in the control group (age, 51.0 [41.8–65.0] years; BMI, 29.4 [25.3–35.8] kg/m2) were analyzed. No significant differences in QoL changes over the intervention period were observed between the two groups. Within the isCGM group, the Mental Component Summary (MCS) score improved significantly (from 44.8 to 48.4, P < 0.05), whereas the Role/Social Component Summary score declined significantly (from 52.2 to 44.8, P < 0.05). Scan frequency correlated positively with baseline Vitality, Mental Health, and MCS scores. Changes in time above range and standard deviation for sensor glucose were negatively correlated with changes in the General Health score.

Conclusion

isCGM did not improve QoL scores relative to the control group for overweight individuals with IGT or mild diabetes. Within-group analysis suggested that isCGM improved mental QoL but lowered perceived social QoL. Tailored support addressing psychological and social needs may maximise isCGM benefits.