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Predictors of the effectiveness of isCGM usage in adults with type 1 diabetes mellitus: post-hoc analysis of the ISCHIA study

  • 期刊论文

  • 发表日期：

    2024年2月15日

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  • Kiminori Hosoda,
  • Kunihiro Nishimura,
  • Yoshihiro Miyamoto,
  • Takashi Murata,
  • Naoki Sakane,
  • Noriko Satoh-Asahara,
  • Masao Toyoda,
  • Yushi Hirota,
  • Munehide Matsuhisa,
  • Akio Kuroda,
  • Ken Kato,
  • Ryuji Kouyama,
  • Junnosuke Miura,
  • Atsuhito Tone,
  • Masato Kasahara,
  • Shu Kasama,
  • Shota Suzuki,
  • Yukie Ito,
  • Tomokazu Watanabe,
  • Akiko Suganuma,
  • Zhuo Shen,
  • Hiroko Kobayashi,
  • Satoshi Takagi,
  • Sari Hoshina,
  • Kanako Shimura,
  • Yukiko Tsuchida,
  • Moritsugu Kimura,
  • Nobumichi Saito,
  • Akira Shimada,
  • Yoichi Oikawa,
  • Atsushi Satomura,
  • Akifumi Haisa,
  • Satoshi Kawashima,
  • Shu Meguro,
  • Hiroshi Itoh,
  • Yoshifumi Saisho,
  • Junichiro Irie,
  • Masami Tanaka,
  • Masanori Mitsuishi,
  • Yuya Nakajima,
  • Jun Inaishi,
  • Kenichiro Kinouchi,
  • Shintaro Yamaguchi,
  • Arata Itoh,
  • Kazutoshi Sugiyama,
  • Kazuma Yagi,
  • Tami Tsuchiya,
  • Noriko Kodani,
  • Ikki Shimizu,
  • Tetsuya Fukuda,
  • Yoshiki Kusunoki,
  • Tomoyuki Katsuno,
  • Yuka Matoba,
  • Yumi Hitaka,
  • Kentaro Abe,
  • Natsuko Tanaka,
  • Ryoko Taniguchi,
  • Toshihiko Nagao,
  • Kazuyuki Hida,
  • Izumi Iseda,
  • Masaya Takeda,
  • Yuichi Matsushita,
  • Masafumi Tenta,
  • Tsuyoshi Tanaka,
  • Kunichi Kouyama,
  • Michiru Fukunaga,
  • Takashi Murata,
  • Yushi Hirota,
  • Kiminori Hosoda,
  • Ken Kato,
  • Kunichi Kouyama,
  • Ryuji Kouyama,
  • Akio Kuroda,
  • Yuka Matoba,
  • Munehide Matsuhisa,
  • Shu Meguro,
  • Junnosuke Miura,
  • Kunihiro Nishimura,
  • Naoki Sakane,
  • Akira Shimada,
  • Shota Suzuki,
  • Atsuhito Tone,
  • Masao Toyoda

摘要

Aim

The Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus (ISCHIA) study was a randomized, crossover trial that reported the decrease in time below range (TBR) by the use of intermittent-scanning continuous glucose monitoring (isCGM) combined with structured education in adults with type 1 diabetes (T1D) treated by multiple daily injections. The participants were instructed to perform frequent scanning of the isCGM sensor (10 times a day or more) and ingest sugar when impending hypoglycemia is suspected by tracking the sensor glucose levels and the trend arrow. We conducted post-hoc analysis to identify factors affecting difference in TBR (∆TBR), in time in range (∆TIR), and in time above range (∆TAR).

Participants and methods

Data from 93 participants who completed the ISCHIA study were used. Multiple regression analyses were performed to identify factors affecting CGM metrics.

Results

Pearson’s correlation analysis showed the negative association between log-transformed scan frequency and with ∆TBR (r = − 0.255, P = 0.015), while there was no significant association of log-transformed scan frequency with ∆TIR (r = 0.172, P = 0.102) and ∆TAR (r = 0.032, P = 0.761), respectively. The log-transformed scan frequency was an independent predictor of ∆TBR (Beta = − 7.712, P = 0.022), but not of ∆TIR(Beta = 7.203, P = 0.091) and of ∆TAR (Beta = 0.514, P = 0.925).

Conclusions

Our findings suggest that more frequent scanning of isCGM may be beneficial to reduce TBR in T1D adults.