We prove Hardy-Sobolev inequalities in weighted Herz-Morrey-Orlicz spaces on \({\mathbb R}^n\) . As an application, we discuss Hardy-Sobolev inequalities for generalized Riesz potentials \(\begin{aligned} & R_{\alpha ,m}f(x) = \int _{{\mathbb R}^n} R_{\alpha ,m} (x,y) f(y) dy, \end{aligned}\) where \(R_{\alpha }(x)=|x|^{\alpha -n}\) and \( \displaystyle {R_{\alpha ,m}(x,y) = R_{\alpha }(x-y) - \sum _{|\ell | \le m-1} \frac{x^{\ell }}{\ell !}(D^{\ell }R_{\alpha })(-y)}. \)