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<p>Preterm birth is a major contributor to neonatal morbidity and mortality. This study evaluated the neonatal Sequential Organ Failure Assessment (nSOFA) score for predicting mortality in preterm neonates (&lt; 34&#xa0;weeks) with respiratory distress syndrome. Among 113 neonates, median (q1, q3) nSOFA scores at 0–6&#xa0;h of life were higher in non-survivors than survivors [4 (4, 6) vs 0 (0, 2); <i>P</i> = 0.001], with an area under the curve (AUC) of 0.80 and a cutoff of 3. Predictive performance improved at 24 ± 3&#xa0;h (AUC 0.93), with higher scores in non-survivors [8 (5, 11) vs 0 (0, 2); <i>P</i> &lt; 0.001] and a cutoff of 4. Neonates with composite morbidity had significantly higher nSOFA scores at both time points.</p>

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Neonatal Sequential Organ Failure Assessment Score (nSOFA) for Prediction of Mortality Among Preterm Neonates with Respiratory Distress Syndrome: A Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2026年5月4日

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  • Vaishali Sahu,
  • Shalini Tripathi,
  • Mala Kumar,
  • S. N. Singh

摘要

Preterm birth is a major contributor to neonatal morbidity and mortality. This study evaluated the neonatal Sequential Organ Failure Assessment (nSOFA) score for predicting mortality in preterm neonates (< 34 weeks) with respiratory distress syndrome. Among 113 neonates, median (q1, q3) nSOFA scores at 0–6 h of life were higher in non-survivors than survivors [4 (4, 6) vs 0 (0, 2); P = 0.001], with an area under the curve (AUC) of 0.80 and a cutoff of 3. Predictive performance improved at 24 ± 3 h (AUC 0.93), with higher scores in non-survivors [8 (5, 11) vs 0 (0, 2); P < 0.001] and a cutoff of 4. Neonates with composite morbidity had significantly higher nSOFA scores at both time points.