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<p>The management of high-risk neuroblastoma has dismal outcomes in low-and-middle-income countries (LMICs). There is limited data on post transplant outcomes of high-risk neuroblastoma from LMICs. We report the outcomes of twelve patients with high-risk neuroblastoma who underwent autologous stem cell transplanatation (ASCT) at a single tertiary care center in Northen India. At a median follow-up of 25.5 months, the event-free survival was 63.6%. Relapse occurred in four patients (33.3%), who subsequently died. All patients had febrile neutropenia; there was no ASCT-related mortality. Multidisciplinary therapy even with omission of dinutuximab in our cohort had acceptable outcomes.</p>

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Post Transplant Outcomes of High-Risk Neuroblastoma From a Tertiary Care Unit in India

  • 期刊论文

  • 发表日期：

    2025年1月30日

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  • Shivam Bansal,
  • Rahul Kumar,
  • Aditya Kumar Gupta,
  • Jagdish Prasad Meena,
  • Rachna Seth

摘要

The management of high-risk neuroblastoma has dismal outcomes in low-and-middle-income countries (LMICs). There is limited data on post transplant outcomes of high-risk neuroblastoma from LMICs. We report the outcomes of twelve patients with high-risk neuroblastoma who underwent autologous stem cell transplanatation (ASCT) at a single tertiary care center in Northen India. At a median follow-up of 25.5 months, the event-free survival was 63.6%. Relapse occurred in four patients (33.3%), who subsequently died. All patients had febrile neutropenia; there was no ASCT-related mortality. Multidisciplinary therapy even with omission of dinutuximab in our cohort had acceptable outcomes.