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Objective <p>To assess the safety, efficacy and outcomes of therapeutic plasma exchange (TPE) in children at a tertiary care hospital.</p> Methods <p>Data of children who underwent TPE between January 2020 and July 2024 at a tertiary care hospital in Eastern part of India, were collected from the hospital records and analyzed.</p> Results <p>Forty children with mean (SD) age of 7.5 (3) years underwent 184 cycles of TPE during the study period. Liver disease was the commonest indication (n=14, 35%) followed by renal diseases (n=11, 27.5%) and secondary hemophagocytic lymphohistiocytosis (HLH, n=9, 22.5%). Out of 40 children,16 were discharged, 21 succumbed to the illness and 3 left against medical advice. Children with autoimmune encephalitis and renal diseases with American Society for Apheresis (ASFA) category I indication for TPE had an excellent outcome as compared to others. However, a high mortality was observed in view of delayed presentation with organ failure and lack of liver transplant facility.</p> Conclusion <p>TPE is an effective treatment in hemolytic uremic syndrome (HUS) and anti-N-methyl-D-aspartate receptor encephalitis. TPE can be performed safely and effectively for renal and non-renal indications.</p>

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Therapeutic Plasma Exchange in Pediatric Care: Insights from a Tertiary Care Centre Experience

  • 期刊论文

  • 发表日期：

    2025年11月24日

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  • Sphurti Chowdhary,
  • Krishna Mohan Gulla,
  • Satya Prakash,
  • Ansuman Sahu,
  • Sandip Panda,
  • Amit Kumar Satapathy

摘要

Objective

To assess the safety, efficacy and outcomes of therapeutic plasma exchange (TPE) in children at a tertiary care hospital.

Methods

Data of children who underwent TPE between January 2020 and July 2024 at a tertiary care hospital in Eastern part of India, were collected from the hospital records and analyzed.

Results

Forty children with mean (SD) age of 7.5 (3) years underwent 184 cycles of TPE during the study period. Liver disease was the commonest indication (n=14, 35%) followed by renal diseases (n=11, 27.5%) and secondary hemophagocytic lymphohistiocytosis (HLH, n=9, 22.5%). Out of 40 children,16 were discharged, 21 succumbed to the illness and 3 left against medical advice. Children with autoimmune encephalitis and renal diseases with American Society for Apheresis (ASFA) category I indication for TPE had an excellent outcome as compared to others. However, a high mortality was observed in view of delayed presentation with organ failure and lack of liver transplant facility.

Conclusion

TPE is an effective treatment in hemolytic uremic syndrome (HUS) and anti-N-methyl-D-aspartate receptor encephalitis. TPE can be performed safely and effectively for renal and non-renal indications.