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Objectives <p>To determine the area under curve (AUC) for vasoactive ventilation renal score (VVRS) &gt; 10 at 24-h of admission for predicting mortality in children aged 1–12&#xa0;years admitted to pediatric intensive care unit (PICU). To also determine the AUC for VVRS &gt; 10 at 48-h of admission for predicting mortality and to determine the AUC of VVRS &gt; 10 at 24-h and 48-h of admission for predicting PICU stay &gt; 3&#xa0;days, hospital stay &gt; 10&#xa0;days and mechanical ventilation &gt; 3&#xa0;days. </p> Methods <p>This observational study included 310 children aged 1–12&#xa0;years admitted in PICU. All required parameters were noted, and VVRS, ventilation index and change in creatinine at 24-h and 48-h of admission were recoded. Receiver operating characteristic curves were computed to determine the predictive role of VVRS &gt; 10 at 24-h and 48-h for mortality, duration of PICU stay, hospital stay and mechanical ventilation.</p> Results <p>Seventy nine (25%) patients succumbed during the study. VVRS &gt; 10 at 24-h and 48-h had a good predictive role for mortality with AUC of 0.873 (sensitivity 89.87%, specificity 69.70%) and 0.996 (sensitivity 96.20%, specificity 96.10%), respectively. Best cutoffs derived for VVRS (24-h), and VVRS (48-h) were &gt; 2.5 and &gt; 13.5. A higher AUC, sensitivity and specificity of VVRS at 48-h were observed for predicting prolonged PICU stay, duration of mechanical ventilation and hospital stay.</p> Conclusions <p>VVRS at 24-h and 48-h has a good predictive role for mortality in children admitted to PICU.</p>

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Vasoactive Ventilation Renal Score as a Predictor of Outcomes in Children Admitted to PICU: An Observational Study

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Shilpi Chauhan,
  • Prerna Batra,
  • Vikram Bhaskar,
  • Piyush Gupta

摘要

Objectives

To determine the area under curve (AUC) for vasoactive ventilation renal score (VVRS) > 10 at 24-h of admission for predicting mortality in children aged 1–12 years admitted to pediatric intensive care unit (PICU). To also determine the AUC for VVRS > 10 at 48-h of admission for predicting mortality and to determine the AUC of VVRS > 10 at 24-h and 48-h of admission for predicting PICU stay > 3 days, hospital stay > 10 days and mechanical ventilation > 3 days.

Methods

This observational study included 310 children aged 1–12 years admitted in PICU. All required parameters were noted, and VVRS, ventilation index and change in creatinine at 24-h and 48-h of admission were recoded. Receiver operating characteristic curves were computed to determine the predictive role of VVRS > 10 at 24-h and 48-h for mortality, duration of PICU stay, hospital stay and mechanical ventilation.

Results

Seventy nine (25%) patients succumbed during the study. VVRS > 10 at 24-h and 48-h had a good predictive role for mortality with AUC of 0.873 (sensitivity 89.87%, specificity 69.70%) and 0.996 (sensitivity 96.20%, specificity 96.10%), respectively. Best cutoffs derived for VVRS (24-h), and VVRS (48-h) were > 2.5 and > 13.5. A higher AUC, sensitivity and specificity of VVRS at 48-h were observed for predicting prolonged PICU stay, duration of mechanical ventilation and hospital stay.

Conclusions

VVRS at 24-h and 48-h has a good predictive role for mortality in children admitted to PICU.