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Purpose <p>To assess the incidence and risk factors for metabolic bone disease of prematurity (MBDP).</p> Methods <p>Infants born at ≤ 33 weeks’ gestation were screened for MBDP using serum calcium, phosphorus, and alkaline phosphatase levels. Screening began at 3-6 weeks and was repeated as indicated until three months of corrected age. Feed volume, nutrient supplementation, and morbidity data were compared between the infants with and without MBDP.</p> Results <p>Among the 153 infants, 22 (14.4%) had moderate MBDP and 28 (18.3%) had severe MBDP. Lower birth weight was independently associated with severe MBDP (<i>P</i>-0.009).</p> Conclusions <p>Nearly 40% of the preterm infants in our cohort had moderate-to-severe MBDP.</p>

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Incidence and Risk Factors for Metabolic Bone Disease of Prematurity in Indian Infants: A Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2025年4月3日

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  • S. B. Mithun Krishna,
  • Jitendra Meena,
  • Jogender Kumar,
  • Kanya Mukhopadhyay,
  • Praveen Kumar

摘要

Purpose

To assess the incidence and risk factors for metabolic bone disease of prematurity (MBDP).

Methods

Infants born at ≤ 33 weeks’ gestation were screened for MBDP using serum calcium, phosphorus, and alkaline phosphatase levels. Screening began at 3-6 weeks and was repeated as indicated until three months of corrected age. Feed volume, nutrient supplementation, and morbidity data were compared between the infants with and without MBDP.

Results

Among the 153 infants, 22 (14.4%) had moderate MBDP and 28 (18.3%) had severe MBDP. Lower birth weight was independently associated with severe MBDP (P-0.009).

Conclusions

Nearly 40% of the preterm infants in our cohort had moderate-to-severe MBDP.