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Objective <p>To determine role of fecal calprotectin (FC) and fecal lactoferrin (FL) in diagnosis of invasive diarrhea.</p> Methods <p>Stool samples from 75 children (≤ 12&#xa0;years) with acute diarrhea were analysed using wet mount microscopy, culture, multiplex polymerase chain reaction, rapid tests for Rotavirus/ Adenovirus and quantitative ELISA for FC and FL.</p> Results <p>The mean (SD) FC levels (μg/g) [774 (626.59) vs. 213 (251.48), <i>P</i> &lt; 0.001] and FL levels (μg/g) [7.95 (4.72) vs. 4.22 (3.91), <i>P</i> = 0.004] were significantly higher in children with invasive diarrhea (<i>n</i> = 38) compared to those with non-invasive diarrhea (<i>n</i> = 37). Cut-off values of FC &gt; 243&#xa0;μg/g (sensitivity 81.57%, specificity 67.56%, AUC 0.813) and for FL &gt; 6.02&#xa0;μg/g (sensitivity 71.05%, specificity 81.08%, AUC 0.732) have diagnostic potential.</p> Conclusions <p>FC and FL can aid diagnosis of acute invasive diarrhea.</p>

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Utility of Fecal Biomarkers to Predict Invasive Nature of Acute Infectious Diarrhea in Indian Children

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Prabhav Aggarwal,
  • Raghvendra Singh,
  • Masoom Nathani,
  • Sonal Saxena,
  • Oves Siddiqui

摘要

Objective

To determine role of fecal calprotectin (FC) and fecal lactoferrin (FL) in diagnosis of invasive diarrhea.

Methods

Stool samples from 75 children (≤ 12 years) with acute diarrhea were analysed using wet mount microscopy, culture, multiplex polymerase chain reaction, rapid tests for Rotavirus/ Adenovirus and quantitative ELISA for FC and FL.

Results

The mean (SD) FC levels (μg/g) [774 (626.59) vs. 213 (251.48), P < 0.001] and FL levels (μg/g) [7.95 (4.72) vs. 4.22 (3.91), P = 0.004] were significantly higher in children with invasive diarrhea (n = 38) compared to those with non-invasive diarrhea (n = 37). Cut-off values of FC > 243 μg/g (sensitivity 81.57%, specificity 67.56%, AUC 0.813) and for FL > 6.02 μg/g (sensitivity 71.05%, specificity 81.08%, AUC 0.732) have diagnostic potential.

Conclusions

FC and FL can aid diagnosis of acute invasive diarrhea.