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Background <p>Cadmium (Cd) has been identified as a neurotoxic agent, leading to various adverse neurological effects, including neurodegeneration, oxidative stress, and inflammation in the brain. This study aimed to investigate the protective effects of <i>Nigella sativa</i> oil (NSO) against Cd-induced alterations in body weight, hematological and biochemical parameters, and the nervous system in mice.</p> Results <p>A total of 60 male Swiss Albino mice, aged 4&#xa0;weeks, were assigned to treatment groups receiving Cd, NSO, or a combination of Cd and NSO. The results demonstrated that Cd significantly reduced body weight and blood parameters, such as TEC, Hb, PCV. However, Cd significantly increased the lipid parameters, such as TC, TG, and LDL, but decreased HDL levels. Whereas, supplementation of mice with NSO reduced the effect of Cd on these parameters. In Cd-exposed mice, a significantly decreased locomotor activity combined with increased anxiety-like behavior was observed by performing behavioral tests, such as open field, the elevated plus maze, light/dark transition test, and force swimming test. The mice treated with NSO showed marked improvements in these neurobehavioral parameters, suggesting a neuroprotective effect. Histological analysis of brain tissue revealed that Cd exposure induced gliosis, perivascular cuffing, and vacuolation of the neuropil. Treatment with NSO significantly reduced the extent of cortical damage.</p> Conclusion <p>The study demonstrates that NSO exhibited significant neuroprotective effects against Cd-induced neurotoxicity in mice. However, further studies investigating oxidative stress, inflammatory responses, and molecular signaling pathways are required to clarify the mechanisms underlying these beneficial effects.</p>

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Role of Nigella sativa oil against cadmium-induced neurotoxicity in mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月14日

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  • Kakoly Sarkar,
  • Md. M. N. Azim,
  • Md. Forhad Hossain,
  • Anandha Mozumder,
  • Md. Golzar Hossain,
  • Yuna Kim,
  • Jun Hong Park,
  • Sharmin Akter

摘要

Background

Cadmium (Cd) has been identified as a neurotoxic agent, leading to various adverse neurological effects, including neurodegeneration, oxidative stress, and inflammation in the brain. This study aimed to investigate the protective effects of Nigella sativa oil (NSO) against Cd-induced alterations in body weight, hematological and biochemical parameters, and the nervous system in mice.

Results

A total of 60 male Swiss Albino mice, aged 4 weeks, were assigned to treatment groups receiving Cd, NSO, or a combination of Cd and NSO. The results demonstrated that Cd significantly reduced body weight and blood parameters, such as TEC, Hb, PCV. However, Cd significantly increased the lipid parameters, such as TC, TG, and LDL, but decreased HDL levels. Whereas, supplementation of mice with NSO reduced the effect of Cd on these parameters. In Cd-exposed mice, a significantly decreased locomotor activity combined with increased anxiety-like behavior was observed by performing behavioral tests, such as open field, the elevated plus maze, light/dark transition test, and force swimming test. The mice treated with NSO showed marked improvements in these neurobehavioral parameters, suggesting a neuroprotective effect. Histological analysis of brain tissue revealed that Cd exposure induced gliosis, perivascular cuffing, and vacuolation of the neuropil. Treatment with NSO significantly reduced the extent of cortical damage.

Conclusion

The study demonstrates that NSO exhibited significant neuroprotective effects against Cd-induced neurotoxicity in mice. However, further studies investigating oxidative stress, inflammatory responses, and molecular signaling pathways are required to clarify the mechanisms underlying these beneficial effects.