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Background <p>Copper oxide nanoparticles (CuONPs) are used in various industrial and commercial applications and are considered a potential hazard to humans and the environment. In particular, inhalation exposure to CuONPs causes severe damage to the respiratory tissue. <i>Camellia sinensis</i> L. is traditionally used to treat various inflammatory disorders and has been experimentally shown to exhibit anti-inflammatory and antioxidant properties due to its bioactive compounds.</p> Objectives <p>This study aimed to investigate the therapeutic effects of <i>Camellia sinensis</i> L. ethanolic extract (CSE) on pulmonary inflammation caused by CuONPs exposure, with an emphasis on the mitogen-activated protein kinase (MAPK) signaling pathway.</p> Results <p>The administration of CSE reduced the inflammatory cell counts including neutrophils and macrophages in mice exposed to CuONPs, as well as the levels of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. These events were accompanied by decreases in inflammatory cell infiltration into pulmonary tissue and mucus production from goblet cells. In addition, the administration of CSE reduced the activation of proteins involved in the MAPK pathway, including p-p38, p-JNK, p-ERK, and MUC5AC induced by CuONPs exposure.</p> Conclusion <p>CSE effectively decreased the pulmonary inflammation caused by CuONPs exposure, which is associated with the suppression of the MAPK signaling pathway. Therefore, this evidence suggests that CSE has potential as a herbal remedy for controlling pulmonary inflammation caused by CuONPs exposure.</p>

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Camellia sinensis (L.) mitigates copper oxide nanoparticles-induced lung inflammation and mucus production through suppressing MAPK signaling and MUC5AC

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Woong-Il Kim,
  • Seol Jang,
  • So-Won Pak,
  • Sin-Hyang Park,
  • Ba-Reun Jin,
  • Jong-Choon Kim,
  • Changjong Moon,
  • Joong-Sun Kim,
  • Young-Kwon Cho,
  • Taesoo Kim,
  • In-Sik Shin

摘要

Background

Copper oxide nanoparticles (CuONPs) are used in various industrial and commercial applications and are considered a potential hazard to humans and the environment. In particular, inhalation exposure to CuONPs causes severe damage to the respiratory tissue. Camellia sinensis L. is traditionally used to treat various inflammatory disorders and has been experimentally shown to exhibit anti-inflammatory and antioxidant properties due to its bioactive compounds.

Objectives

This study aimed to investigate the therapeutic effects of Camellia sinensis L. ethanolic extract (CSE) on pulmonary inflammation caused by CuONPs exposure, with an emphasis on the mitogen-activated protein kinase (MAPK) signaling pathway.

Results

The administration of CSE reduced the inflammatory cell counts including neutrophils and macrophages in mice exposed to CuONPs, as well as the levels of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. These events were accompanied by decreases in inflammatory cell infiltration into pulmonary tissue and mucus production from goblet cells. In addition, the administration of CSE reduced the activation of proteins involved in the MAPK pathway, including p-p38, p-JNK, p-ERK, and MUC5AC induced by CuONPs exposure.

Conclusion

CSE effectively decreased the pulmonary inflammation caused by CuONPs exposure, which is associated with the suppression of the MAPK signaling pathway. Therefore, this evidence suggests that CSE has potential as a herbal remedy for controlling pulmonary inflammation caused by CuONPs exposure.