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Background <p>Obstructive sleep apnea (OSA) is one of the most common sleep disorders and is characterized by intermittent hypoxia (IH) and sleep fragmentation. It is known that aging is a risk factor for OSA development, however, the potential influences of OSA on the aging have not been widely investigated.</p> Objective <p>In this study, we evaluated the impact of intermittent hypoxia (IH) on elderly mouse model.</p> Results <p>The mice were randomly divided into four groups: young + room air (RA) (YC), elderly + RA (EC), young + IH (YI), and elderly + IH (EI). Mice (C57BL/6, female) were exposed to RA or IH (20 cycles/h, FiO<sub>2</sub> nadir 7 ± 0.5%, 8&#xa0;h/day) for 4&#xa0;weeks. The mice were sacrificed at day 28. The EI group showed a trend of more severe inflammation, fibrosis, and oxidative stress compared to the other groups, including the YC group. Inflammatory cytokines such as IL12p70, TNF, IFN-γ, IL-10, IL-6 from serum increased significantly in the EI group compared to the other groups. In addition, the EI group showed significantly more increased leukocyte count compared to room air-treated groups and a trend of more inflammatory cytokines in the bronchoalveolar (BAL) fluid compared to other groups. In neuromuscular coordination test, the elderly mouse showed a significant decrease compared to the young mouse, particularly in the elderly mouse with IH-induced sleep apnea.</p> Conclusion <p>This study shows the possible harmful impact of IH on aging in a mouse model. This result suggests that older patients with OSA may be more of a concern. Further research into the mechanisms underlying the effects of IH on systemic and lung infection in aging is needed.</p>

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Aging and the effects of chronic intermittent hypoxia caused by obstructive sleep apnea

  • 期刊论文

  • 发表日期：

    2025年7月15日

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  • Heayon Lee,
  • Bora Lee,
  • Sei Won Kim,
  • Chang Dong Yeo,
  • In Kyoung Kim,
  • Sang Haak Lee

摘要

Background

Obstructive sleep apnea (OSA) is one of the most common sleep disorders and is characterized by intermittent hypoxia (IH) and sleep fragmentation. It is known that aging is a risk factor for OSA development, however, the potential influences of OSA on the aging have not been widely investigated.

Objective

In this study, we evaluated the impact of intermittent hypoxia (IH) on elderly mouse model.

Results

The mice were randomly divided into four groups: young + room air (RA) (YC), elderly + RA (EC), young + IH (YI), and elderly + IH (EI). Mice (C57BL/6, female) were exposed to RA or IH (20 cycles/h, FiO2 nadir 7 ± 0.5%, 8 h/day) for 4 weeks. The mice were sacrificed at day 28. The EI group showed a trend of more severe inflammation, fibrosis, and oxidative stress compared to the other groups, including the YC group. Inflammatory cytokines such as IL12p70, TNF, IFN-γ, IL-10, IL-6 from serum increased significantly in the EI group compared to the other groups. In addition, the EI group showed significantly more increased leukocyte count compared to room air-treated groups and a trend of more inflammatory cytokines in the bronchoalveolar (BAL) fluid compared to other groups. In neuromuscular coordination test, the elderly mouse showed a significant decrease compared to the young mouse, particularly in the elderly mouse with IH-induced sleep apnea.

Conclusion

This study shows the possible harmful impact of IH on aging in a mouse model. This result suggests that older patients with OSA may be more of a concern. Further research into the mechanisms underlying the effects of IH on systemic and lung infection in aging is needed.