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Background <p><i>Porphyridium cruentum</i> (<i>P. cruentum</i>) is a red marine seaweed that belongs to the Porphyridiophyceae family. It has no cell wall on its surface, but it contains a high amount of polysaccharides. It also contains proteins, fatty acids, carotenoids, and phycoerythrin-like substances. It exhibits anti-inflammatory, antioxidant, and anti-proliferative activities. It is found in various regions, such as the coastlines of France, Australia, and India.</p> Objectives <p>This study aimed to evaluate the anti-melanogenesis, and tyrosinase inhibitory properties of <i>P. cruentum</i>.</p> Results <p>Molecular docking studies showed that the binding of phycoerythrin, zeaxanthin, and β-carotenoid indicated a significant binding affinity to the target receptor and could be applied as lead molecules to inhibit tyrosinase. The cytotoxicity assay on B16F10 mouse melanoma cells showed no toxic effect of <i>P. cruentum</i> at 200&#xa0;µg/ml concentration. <i>P. cruentum</i> &lt; 50&#xa0;μg/ml concentration showed great melanin inhibitory effect. The mushroom tyrosinase assay showed a greater reduction in tyrosinase of <i>P. cruentum</i> than kojic acid. The zebrafish embryo model was used to estimate melanin concentration in zebrafish embryos, which shows a great decrease in melanin.</p> Conclusions <p>All the above studies have clearly shown a good reducing capacity of melanin and can be greatly introduced in cosmeceuticals for anti-melanin and whitening purposes after clinical studies.</p>

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Anti-melanogenic and anti-hyperpigmentation effects of Porphyridium cruentum: in-silico, in-vitro, and in-vivo approach

  • 期刊论文

  • 发表日期：

    2025年3月11日

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  • Neha Nilam,
  • Abhisek Pal,
  • Pritipadma Panda,
  • Manasi Sandeep Birje

摘要

Background

Porphyridium cruentum (P. cruentum) is a red marine seaweed that belongs to the Porphyridiophyceae family. It has no cell wall on its surface, but it contains a high amount of polysaccharides. It also contains proteins, fatty acids, carotenoids, and phycoerythrin-like substances. It exhibits anti-inflammatory, antioxidant, and anti-proliferative activities. It is found in various regions, such as the coastlines of France, Australia, and India.

Objectives

This study aimed to evaluate the anti-melanogenesis, and tyrosinase inhibitory properties of P. cruentum.

Results

Molecular docking studies showed that the binding of phycoerythrin, zeaxanthin, and β-carotenoid indicated a significant binding affinity to the target receptor and could be applied as lead molecules to inhibit tyrosinase. The cytotoxicity assay on B16F10 mouse melanoma cells showed no toxic effect of P. cruentum at 200 µg/ml concentration. P. cruentum < 50 μg/ml concentration showed great melanin inhibitory effect. The mushroom tyrosinase assay showed a greater reduction in tyrosinase of P. cruentum than kojic acid. The zebrafish embryo model was used to estimate melanin concentration in zebrafish embryos, which shows a great decrease in melanin.

Conclusions

All the above studies have clearly shown a good reducing capacity of melanin and can be greatly introduced in cosmeceuticals for anti-melanin and whitening purposes after clinical studies.