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Background <p>Hyperglycemia, a hallmark of type 2 diabetes mellitus (T2DM), induces oxidative stress in various physiological systems. Alkaline reduced water (ARW) has demonstrated antioxidant properties in vitro, owing to its bioactive characteristics. This study aimed to evaluate the effects of alkaline reduced water (pH 8.5) in a T2DM C57BL/6 mouse model, induced by high-fat diet and streptozotocin.</p> Methods and results <p>After the induction of T2DM, the mice were treated with tap water (pH 7.7), metformin, and ARW (pH 8.5) for 4&#xa0;weeks. Post-treatment assessments included total white blood cell count and its differential counts, oxidative stress markers (reactive oxygen species, nitric oxide, glutathione peroxidase, and catalase), and other indicators such as fasting blood glucose, serum glucose, kidney markers (blood urea nitrogen and creatinine), liver markers (alanine aminotransferase and aspartate aminotransferase), serum calcium, adenosine triphosphate, C-peptide, parathyroid hormone, and inflammatory cytokines. ARW (pH 8.5) significantly improved glycemic control, reduced oxidative stress markers, enhanced antioxidant enzyme activities, and decreased inflammatory and diabetic markers.</p> Conclusions <p>ARW (pH 8.5) treatment enhanced antioxidant defenses and moderated inflammation, improving cellular metabolism and mitigating hyperglycemia-related adverse effects in the T2DM C57BL/6 mouse model. These results suggest that ARW (pH 8.5) could be a promising therapeutic approach for reducing oxidative stress and inflammation in T2DM.</p>

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Therapeutic effects of alkaline reduced water on type 2 diabetes mellitus induced by high-fat diet and streptozotocin in C57BL/6 mouse model

  • 期刊论文

  • 发表日期：

    2025年1月24日

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  • Hui Ma,
  • Un Mo Jeong,
  • Johny Bajgai,
  • Md. Habibur Rahman,
  • Chaodeng Mo,
  • Wenjing He,
  • Sofian Abdul-Nasir,
  • Thu Thao Pham,
  • Haiyang Zhang,
  • Seong Hoon Goh,
  • Bomi Kim,
  • Hyeran Jung,
  • Cheol-Su Kim,
  • Kyu-Jae Lee

摘要

Background

Hyperglycemia, a hallmark of type 2 diabetes mellitus (T2DM), induces oxidative stress in various physiological systems. Alkaline reduced water (ARW) has demonstrated antioxidant properties in vitro, owing to its bioactive characteristics. This study aimed to evaluate the effects of alkaline reduced water (pH 8.5) in a T2DM C57BL/6 mouse model, induced by high-fat diet and streptozotocin.

Methods and results

After the induction of T2DM, the mice were treated with tap water (pH 7.7), metformin, and ARW (pH 8.5) for 4 weeks. Post-treatment assessments included total white blood cell count and its differential counts, oxidative stress markers (reactive oxygen species, nitric oxide, glutathione peroxidase, and catalase), and other indicators such as fasting blood glucose, serum glucose, kidney markers (blood urea nitrogen and creatinine), liver markers (alanine aminotransferase and aspartate aminotransferase), serum calcium, adenosine triphosphate, C-peptide, parathyroid hormone, and inflammatory cytokines. ARW (pH 8.5) significantly improved glycemic control, reduced oxidative stress markers, enhanced antioxidant enzyme activities, and decreased inflammatory and diabetic markers.

Conclusions

ARW (pH 8.5) treatment enhanced antioxidant defenses and moderated inflammation, improving cellular metabolism and mitigating hyperglycemia-related adverse effects in the T2DM C57BL/6 mouse model. These results suggest that ARW (pH 8.5) could be a promising therapeutic approach for reducing oxidative stress and inflammation in T2DM.