Plantamajoside ameliorates TGFβ2-induced autophagy, epithelial–mesenchymal transition and inflammatory processes in human lens epithelial cells

期刊论文
发表日期：

2024年5月14日

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Xiaoxiang Sun,
Xuequan Sun,
Xinyan Xu,
Yuxuan Wang,
Susu Lu

摘要

Background

Posterior capsular opacification (PCO) is the most common postoperative complication after cataract surgery, occurring in > 25% of adults. To combat this disease, new and more targets and drugs are still urgently needed. Plantamajoside (PMS) is a natural compound extracted from planajoside and has a wide range of biological activities. However, the role and effects of PMS in PCO are still unclear.

Objectives

To uncover the possible effects of plantamajoside (PMS) on posterior capsular opacification (PCO) progression and clarify the mechanism.

Results

PMS inhibited the proliferation of hLECs. PMS inhibited the autophagy of hLECs. Furthermore, PMS suppressed the motility and EMT of hLECs induced by TGFβ2. PMS suppressed the TGFβ2-induced inflammation of hLECs. Mechanically, PMS restrained the AGEs–RAGE axis, therefore, inhibiting PCO progression.

Conclusion

PMS could serve as a promising drug for PCO treatment.