FAM120A promotes angiogenesis in pancreatic cancer by increasing the mRNA expression of RHOA

期刊论文
发表日期：

2024年5月16日

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Yifeng Wu,
Jiye Feng,
Chang Xin,
Zongyang Wu,
Minmin Cai,
Wenyi Xu

摘要

Background

Pancreatic cancer (PAAD) is an aggressive malignancy with poor prognosis. The development of effective anti-angiogenesis drugs is of great importance for the improvement of the prognosis of PAAD. FAM120A, also known as c9orf10, is an RNA-binding protein (RBP). FAM120A is overexpressed in multiple tumors, and affected the progression of tumors. However, FAM120A is rarely reported in pancreatic cancer, and the mechanism is unclear.

Objective

To investigate the effects of FAM120A on the growth and vascularization of pancreatic cancer (PAAD) and explore the underlying mechanism.

Results

FAM120A was highly expressed in PAAD cells. FAM120A knockdown restrained the growth of PAAD cells and suppressed the vascularization as well as migration of PAAD cells. Moreover, FAM120A regulated the mRNA expression of RHOA in PAAD cells, and overexpression of RHOA reversed the anti-tumor effect of FAM120A knockdown.

Conclusion

FAM120A contributed to the angiogenesis of PAAD by increasing the mRNA expression of RHOA.

Graphical Abstract