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Background <p>Lymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding protein B (RalB) have been recently described that it was involved in tumor growth and metastasis, but the effect in TSCC is still ill-defined.</p> Objective <p>This study provides insights into the role of <i>RALB</i> as a prognostic factor in head and neck squamous cell carcinoma (HNSCC) and demonstrates its involvement in promoting lymph node metastasis in TSCC.</p> Methods <p>Firstly, the expression level of <i>RALB</i> and the relationship with clinical features were examined. Subsequently, <i>RALB</i> knockdown Cal-27 cells orthotopic xenotransplantation in the tongue of BALB/c nude mice were established. Finally, using Connectivity Map (CMAP) database to find possible drugs.</p> Results <p>Firstly, <i>RALB</i> could not only predict the cancer patients’ prognosis and survival and but also act as a potential prognostic factor, particularly in HNSCC by pan-cancer bioinformatics analysis. In addition, we found that RalB promoted tumor growth and lymph node metastasis. Finally, we identified Tirabrutinib (ONO-4059) targeting RalB with good binding properties.</p> Conclusions <p>RalB act as a prognostic gene in HNSCC, and promote lymph node metastasis in early stage of TSCC.</p>

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RalB promotes lymph node metastasis in tongue squamous cell carcinoma

  • 期刊论文

  • 发表日期：

    2025年4月10日

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  • Yuman Zhang,
  • Jiali Yang,
  • Yi Gong,
  • Zhihan Liu,
  • Yanguang Yang,
  • Xiaoyong Song,
  • Yuting Gao,
  • Yajun Xiong,
  • Dan Wang,
  • Kai Fu,
  • Lifeng Jia,
  • Xinli Shi

摘要

Background

Lymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding protein B (RalB) have been recently described that it was involved in tumor growth and metastasis, but the effect in TSCC is still ill-defined.

Objective

This study provides insights into the role of RALB as a prognostic factor in head and neck squamous cell carcinoma (HNSCC) and demonstrates its involvement in promoting lymph node metastasis in TSCC.

Methods

Firstly, the expression level of RALB and the relationship with clinical features were examined. Subsequently, RALB knockdown Cal-27 cells orthotopic xenotransplantation in the tongue of BALB/c nude mice were established. Finally, using Connectivity Map (CMAP) database to find possible drugs.

Results

Firstly, RALB could not only predict the cancer patients’ prognosis and survival and but also act as a potential prognostic factor, particularly in HNSCC by pan-cancer bioinformatics analysis. In addition, we found that RalB promoted tumor growth and lymph node metastasis. Finally, we identified Tirabrutinib (ONO-4059) targeting RalB with good binding properties.

Conclusions

RalB act as a prognostic gene in HNSCC, and promote lymph node metastasis in early stage of TSCC.