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<p>Chromosome region maintenance 1 (CRM1) is a key nuclear export receptor that mediates the transport of numerous proteins and RNA species from the nucleus to the cytoplasm via the classical leucine-rich nuclear export signal (NES) pathway. In normal cells, CRM1 plays a critical role in maintaining cellular homeostasis by regulating the spatial and temporal distribution of important signaling molecules, transcription factors, and tumor suppressor proteins. However, dysregulation of CRM1 function is frequently observed during cancer progression. A deeper understanding of the biology of CRM1 and pathways associated with it in both healthy and cancerous contexts may provide novel opportunities for targeted intervention and improved clinical outcomes. This review discusses the functional relevance of CRM1 in different cancers and evaluates the potential of CRM1 inhibitors in anti-cancer therapy. This article aligns with SDG 3 (Good Health and Well-Being) of the UN Agenda for Sustainable Development.</p>

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CRM1 as a potential biomarker and therapeutic target in cancer: a comprehensive review

  • 期刊论文

  • 发表日期：

    2026年6月26日

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  • Seema Yadav,
  • Anshul Shinde,
  • Jyoti Rani,
  • Ravindresh Chhabra

摘要

Chromosome region maintenance 1 (CRM1) is a key nuclear export receptor that mediates the transport of numerous proteins and RNA species from the nucleus to the cytoplasm via the classical leucine-rich nuclear export signal (NES) pathway. In normal cells, CRM1 plays a critical role in maintaining cellular homeostasis by regulating the spatial and temporal distribution of important signaling molecules, transcription factors, and tumor suppressor proteins. However, dysregulation of CRM1 function is frequently observed during cancer progression. A deeper understanding of the biology of CRM1 and pathways associated with it in both healthy and cancerous contexts may provide novel opportunities for targeted intervention and improved clinical outcomes. This review discusses the functional relevance of CRM1 in different cancers and evaluates the potential of CRM1 inhibitors in anti-cancer therapy. This article aligns with SDG 3 (Good Health and Well-Being) of the UN Agenda for Sustainable Development.