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<p>This study investigates the presence and distribution of three synonymous single nucleotide variants (sSNVs) i.e. rs2304669, rs2304670 and rs2304671 of the <i>Per2</i> gene in control vs. addicted population who reside in Kolkata, an eastern Indian region. These sSNVs are located within the CK1ε (Casein Kinase 1 epsilon) binding domain of <i>Per2</i>, a critical region responsible for regulating the protein’s stability, localization, and function through phosphorylation. A total of five single nucleotide variants (SNVs) of <i>Per2</i> were analyzed among three groups: opioid addicted, alcohol addicted, and controls. Our finding is the first report, where we confirmed the presence of three sSNVs in the studied population. Results showed that the mutant GA genotype of rs2304671, both the GA genotype and the minor allele A of rs2304670 were more prevalent in the opioid-addicted population than in controls. Again, rs2304669 variant displayed an increased frequency of the AG genotype and minor allele G in the alcoholic group than control. These results of increased frequency of <i>Per2</i> variants among opioid or alcoholic users suggest a chance of potential involvement of the same in addiction mechanisms. Consequently, these findings underscore the importance of exploring the role of <i>Per2</i> genetic variability in drug addiction, highlighting the need for further research to elucidate the specific contributions of these sSNVs in addiction susceptibility and related behavioral outcomes.</p>

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Increased frequency of specific Per2 gene variants in opioid and alcohol users: Evidences from a case–control study in East Indian population

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Kaninika Roy,
  • Ishani Deb

摘要

This study investigates the presence and distribution of three synonymous single nucleotide variants (sSNVs) i.e. rs2304669, rs2304670 and rs2304671 of the Per2 gene in control vs. addicted population who reside in Kolkata, an eastern Indian region. These sSNVs are located within the CK1ε (Casein Kinase 1 epsilon) binding domain of Per2, a critical region responsible for regulating the protein’s stability, localization, and function through phosphorylation. A total of five single nucleotide variants (SNVs) of Per2 were analyzed among three groups: opioid addicted, alcohol addicted, and controls. Our finding is the first report, where we confirmed the presence of three sSNVs in the studied population. Results showed that the mutant GA genotype of rs2304671, both the GA genotype and the minor allele A of rs2304670 were more prevalent in the opioid-addicted population than in controls. Again, rs2304669 variant displayed an increased frequency of the AG genotype and minor allele G in the alcoholic group than control. These results of increased frequency of Per2 variants among opioid or alcoholic users suggest a chance of potential involvement of the same in addiction mechanisms. Consequently, these findings underscore the importance of exploring the role of Per2 genetic variability in drug addiction, highlighting the need for further research to elucidate the specific contributions of these sSNVs in addiction susceptibility and related behavioral outcomes.