<p><i>Uraria picta</i> is a medicinally important leguminous plant widely recognized in Ayurveda for its therapeutic properties, particularly in tissue regeneration, wound healing, and anti-inflammatory applications. In order to identify better genotypes to facilitate breeding and realize its planned cultivation, a systematic study was conducted to investigate the changes in adaptation responsiveness of its 24 diverse genotypes of over 4&#xa0;years. The regression coefficient (bi) and s²di values were non-significant for numerous genotypes. One of the 24 genotypes studied, UP-50, was shown to be an appropriate and stable genotype for all variables except rhoifolin (%) in roots, where genotype UP-47 was the highest yielder over all 4&#xa0;years and conditions. The present findings show that the parameters influencing stability performance differ by genotype. To breed stable genotypes, it is important to consider all three stability indices (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\({\bar{\text{x}}}\)</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mrow> <mtext>x</mtext> </mrow> <mrow> <mo stretchy="false">¯</mo> </mrow> </mover> </math></EquationSource> </InlineEquation>, bi, and s²di). The genotypes UP-50, UP-49, and UP-47 were shown to be suitable for use in <i>U. picta</i> breeding programs to produce more steady lines with improved performance.</p>