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<p>A multifunctional advanced material that integrates antibacterial activity, anti-inflammatory effects, and tissue regenerative capability represents a highly effective platform for the treatment of infected wounds. Among various candidates, in situ–forming hydrogels have gained significant attention owing to their favorable physicochemical characteristics and biological performance. <i>Chromolaena odorata</i> (CO) leaves, traditionally used for their antibacterial and wound healing effects, contain abundant phenolic and polyphenolic compounds that also enable them to function as effective reducing and capping agents for silver nanoparticle (AgNPs) synthesis. In this study, we developed a multifunctional thermoresponsive nanocomposite hydrogel by incorporating AgNPs and CO extract into a chitosan-based polymer matrix. This integration improved the mechanical robustness of the system and conferred multiple bioactivities, including antioxidant, antimicrobial, anti-inflammatory, and cell proliferative effects, while preserving its injectability and temperature-triggered gelation behavior. The hydrogel demonstrated enhanced proliferation of human fibroblasts, strong free-radical scavenging capacity, and potent antibacterial activity against both <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. These findings support the potential of this multifunctional hydrogel platform for further development and application in the treatment of infected skin wounds.</p> Graphical abstract <p></p>

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Thermally injectable silver nanoparticle–chitosan composite hydrogels as advanced materials for infected wound healing

  • 期刊论文

  • 发表日期：

    2026年5月5日

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  • Anh Quan Hoang,
  • Dinh Trung Nguyen,
  • Le Nguyen Tuong Vi,
  • Phuong Tung Nguyen,
  • Van Du Cao,
  • Phuong Le Thi

摘要

A multifunctional advanced material that integrates antibacterial activity, anti-inflammatory effects, and tissue regenerative capability represents a highly effective platform for the treatment of infected wounds. Among various candidates, in situ–forming hydrogels have gained significant attention owing to their favorable physicochemical characteristics and biological performance. Chromolaena odorata (CO) leaves, traditionally used for their antibacterial and wound healing effects, contain abundant phenolic and polyphenolic compounds that also enable them to function as effective reducing and capping agents for silver nanoparticle (AgNPs) synthesis. In this study, we developed a multifunctional thermoresponsive nanocomposite hydrogel by incorporating AgNPs and CO extract into a chitosan-based polymer matrix. This integration improved the mechanical robustness of the system and conferred multiple bioactivities, including antioxidant, antimicrobial, anti-inflammatory, and cell proliferative effects, while preserving its injectability and temperature-triggered gelation behavior. The hydrogel demonstrated enhanced proliferation of human fibroblasts, strong free-radical scavenging capacity, and potent antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa. These findings support the potential of this multifunctional hydrogel platform for further development and application in the treatment of infected skin wounds.

Graphical abstract