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<p>Injured tissues often require immediate closure to restore the normal functionality of the organ. However, most hydrogels used in wound healing have poor adhesion to the tissue and weak elastic properties, limiting their ability to provide effective wound protection. Additionally, hydrogels with self-healing capacity can automatically repair themselves after mechanical damage, extending their lifespan and providing better wound protection, especially in critical situations. This study explores the influence of oxidized pullulan concentration on the bioadhesive, and physicochemical properties of chitosan and pullulan (CS/APUL) hydrogels. The adhesive strength, rheological test, thermal analysis, morphology, chemical nature, and swelling studies of the hydrogels were investigated. The findings demonstrated that the CS/APUL hydrogels rapidly formed self-healing scaffolds and exhibited improved elastic strength and tunable adhesion ranging from 16 ± 1.0 to 30.3 ± 2.52&#xa0;kPa. The adhesive properties of the gels were attributed to the presence of aldehydes and amino groups. In addition, the CS/APUL hydrogels strength increased from 661.2 ± 228.5 to 1482 ± 504.0&#xa0;Pa. Therefore, the CS/APUL hydrogels can be used for various applications, such as wound dressings and adhesives.</p> Graphical Abstract <p>Synthesis of tissue adhesive, self-healing and injectable chitosan/pullulan hydrogels via Schiff base reaction</p> <p></p>

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Tunable hydrogel properties: effect of polymer ratio in chitosan/oxidized pullulan adhesive networks

  • 期刊论文

  • 发表日期：

    2025年10月17日

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  • Collins N. Elangwe,
  • Mayya V. Uspenskaya,
  • Roman O. Olekhnovich

摘要

Injured tissues often require immediate closure to restore the normal functionality of the organ. However, most hydrogels used in wound healing have poor adhesion to the tissue and weak elastic properties, limiting their ability to provide effective wound protection. Additionally, hydrogels with self-healing capacity can automatically repair themselves after mechanical damage, extending their lifespan and providing better wound protection, especially in critical situations. This study explores the influence of oxidized pullulan concentration on the bioadhesive, and physicochemical properties of chitosan and pullulan (CS/APUL) hydrogels. The adhesive strength, rheological test, thermal analysis, morphology, chemical nature, and swelling studies of the hydrogels were investigated. The findings demonstrated that the CS/APUL hydrogels rapidly formed self-healing scaffolds and exhibited improved elastic strength and tunable adhesion ranging from 16 ± 1.0 to 30.3 ± 2.52 kPa. The adhesive properties of the gels were attributed to the presence of aldehydes and amino groups. In addition, the CS/APUL hydrogels strength increased from 661.2 ± 228.5 to 1482 ± 504.0 Pa. Therefore, the CS/APUL hydrogels can be used for various applications, such as wound dressings and adhesives.

Graphical Abstract

Synthesis of tissue adhesive, self-healing and injectable chitosan/pullulan hydrogels via Schiff base reaction