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<p>The primary objective of this study was to develop a novel polyelectrolyte multilayer (PEM) coating incorporating drug-loaded microspheres (MS) for medical devices, with a focus on optimizing coatings for silicone surfaces used in biomedical applications. Quaternary ammonium salt chitosan (HTCC) was synthesized through chitosan modification and confirmed by Fourier transform infrared spectroscopy (FT-IR). Poly(lactic-co-glycolic acid) (PLGA) MS, loaded with coumarin-6, were prepared and characterized by scanning electron microscopy and FT-IR, confirming effective encapsulation without chemical alteration. Silicone sheets were modified with a polydopamine layer, enabling a layer-by-layer assembly of HTCC and poly(acrylic acid) (PAA). MS were then applied and secured with an additional PEM coating, quantified by fluorescence. The coatings were evaluated for stability, thickness, and water contact angle, with optimal results achieved using double HTCC layers, leading to uniform and stable MS deposition. The subsequent PEM coatings significantly enhanced the hydrophilicity and coating thickness of the silicone surface. Stability tests under shear stress confirmed the ability of PEM coatings to retain MS attachment, enabling sustained drug release and prolonged implant functionality. This multifunctional coating system for silicone medical devices demonstrates improved drug loading and extended release duration by employing polydopamine as a base layer along with PLGA-MS and polyelectrolytes, thereby&#xa0;highlighting&#xa0;its potential for enhanced drug delivery and device performance in medical applications.</p> Graphical abstract <p></p>

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Layer-by-layer coating of drug-loaded microspheres on silicone surfaces for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年8月14日

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  • Seonghun Lee,
  • Junhyeung Park,
  • Simmyung Yook,
  • Jee-Heon Jeong

摘要

The primary objective of this study was to develop a novel polyelectrolyte multilayer (PEM) coating incorporating drug-loaded microspheres (MS) for medical devices, with a focus on optimizing coatings for silicone surfaces used in biomedical applications. Quaternary ammonium salt chitosan (HTCC) was synthesized through chitosan modification and confirmed by Fourier transform infrared spectroscopy (FT-IR). Poly(lactic-co-glycolic acid) (PLGA) MS, loaded with coumarin-6, were prepared and characterized by scanning electron microscopy and FT-IR, confirming effective encapsulation without chemical alteration. Silicone sheets were modified with a polydopamine layer, enabling a layer-by-layer assembly of HTCC and poly(acrylic acid) (PAA). MS were then applied and secured with an additional PEM coating, quantified by fluorescence. The coatings were evaluated for stability, thickness, and water contact angle, with optimal results achieved using double HTCC layers, leading to uniform and stable MS deposition. The subsequent PEM coatings significantly enhanced the hydrophilicity and coating thickness of the silicone surface. Stability tests under shear stress confirmed the ability of PEM coatings to retain MS attachment, enabling sustained drug release and prolonged implant functionality. This multifunctional coating system for silicone medical devices demonstrates improved drug loading and extended release duration by employing polydopamine as a base layer along with PLGA-MS and polyelectrolytes, thereby highlighting its potential for enhanced drug delivery and device performance in medical applications.

Graphical abstract