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<p>Corneal diseases represent a significant global health challenge, often leading to diminished vision or blindness if left untreated. This study presents a novel hydrogel that combines electrospun gelatin (GE) nanofibers with hyaluronic acid (HA) to closely replicate the structural and functional attributes of the human cornea. Through a dual crosslinking process utilizing glutaraldehyde and EDC/NHS, we developed a composite material with high transparency, remarkable mechanical strength, and excellent cytocompatibility. Our hydrogel achieved 98% optical transmittance, closely matching the clarity of the native cornea, and attained a tensile modulus of 3.141&#xa0;MPa, comparable to that of corneal tissue. These properties were maintained alongside high permeability and controlled degradability, essential for long-term ocular application. This novel hydrogel serves as a promising solution to the challenges of corneal transplantation and ocular surface disorders by providing a synthetic alternative that closely replicates the essential qualities of corneal tissue.</p> Graphical abstract <p>A novel hydrogel combining electrospun gelatin nanofibers with hyaluronic acid mimics the human cornea’s structure and function, offering high transparency, mechanical strength, and biocompatibility as a promising synthetic material for corneal applications.</p> <p></p>

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A cornea-mimetic electrospun fiber-reinforced hydrogel platform for ocular surface applications

  • 期刊论文

  • 发表日期：

    2025年2月3日

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  • Karen Chen,
  • Euisun Song,
  • Wong-Gun Koh,
  • David Myung

摘要

Corneal diseases represent a significant global health challenge, often leading to diminished vision or blindness if left untreated. This study presents a novel hydrogel that combines electrospun gelatin (GE) nanofibers with hyaluronic acid (HA) to closely replicate the structural and functional attributes of the human cornea. Through a dual crosslinking process utilizing glutaraldehyde and EDC/NHS, we developed a composite material with high transparency, remarkable mechanical strength, and excellent cytocompatibility. Our hydrogel achieved 98% optical transmittance, closely matching the clarity of the native cornea, and attained a tensile modulus of 3.141 MPa, comparable to that of corneal tissue. These properties were maintained alongside high permeability and controlled degradability, essential for long-term ocular application. This novel hydrogel serves as a promising solution to the challenges of corneal transplantation and ocular surface disorders by providing a synthetic alternative that closely replicates the essential qualities of corneal tissue.

Graphical abstract

A novel hydrogel combining electrospun gelatin nanofibers with hyaluronic acid mimics the human cornea’s structure and function, offering high transparency, mechanical strength, and biocompatibility as a promising synthetic material for corneal applications.