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<p>In this study, we report the effects of fibroblast growth factor-7 (FGF-7) concentration on wound healing, which has been less extensively studied compared to other growth factors. Assessment of the concentration-dependent effects of FGF-7 in an in vitro cell scratch assay showed that FGF-7 promoted human HaCaT keratinocyte migration into the wound area. In an in vivo animal test, local treatment with FGF-7 (up to 100&#xa0;μg) resulted in no toxicity. In addition, we found that when 100&#xa0;μg of FGF-7 was administered, transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), and hydroxyproline, which are all related to wound healing, were significantly upregulated, followed by accelerated wound healing. All our results demonstrated that the FGF-7 concentration affects wound healing, and a dose of 100&#xa0;μg of FGF-7 exhibited the most pronounced wound healing effect.</p> Graphical abstract <p>Increased wound recovery effect according to increased FGF-7 concentration in an in vivo wound model</p>

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FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression

  • 期刊论文

  • 发表日期：

    2025年1月9日

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  • Young-Sik Kim,
  • Gun-Jae Jeong,
  • Jung Soo Lee,
  • Ju Woong Jang,
  • Sae Hyun Kim,
  • Heung Jae Chun,
  • Dae Hyeok Yang

摘要

In this study, we report the effects of fibroblast growth factor-7 (FGF-7) concentration on wound healing, which has been less extensively studied compared to other growth factors. Assessment of the concentration-dependent effects of FGF-7 in an in vitro cell scratch assay showed that FGF-7 promoted human HaCaT keratinocyte migration into the wound area. In an in vivo animal test, local treatment with FGF-7 (up to 100 μg) resulted in no toxicity. In addition, we found that when 100 μg of FGF-7 was administered, transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), and hydroxyproline, which are all related to wound healing, were significantly upregulated, followed by accelerated wound healing. All our results demonstrated that the FGF-7 concentration affects wound healing, and a dose of 100 μg of FGF-7 exhibited the most pronounced wound healing effect.

Graphical abstract

Increased wound recovery effect according to increased FGF-7 concentration in an in vivo wound model