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Background <p>Women experiencing labor pain undergo significant psychological and physiological challenges, often leading to increased rates of cesarean sections.</p> <p>Epidural analgesia has proven effective in managing labor pain, but its efficacy varies among individuals, partly due to genetic differences, including variations in the COMT gene, which influences pain perception pathways.</p> Methodology <p>Fifty-three hospitalized patients provided informed consent to participate in this study. Peripheral venous blood samples were collected in EDTA tubes for DNA isolation and Polymerase Chain Reaction (PCR) analysis to investigate COMT gene polymorphisms. Epidural analgesia (Fentanyl with Ropivacaine) was administered upon reaching regular uterine contractions and cervical dilation of 4–5 cm. Pain and anxiety levels were assessed using the Visual Analog Scale (VAS) and State Anxiety Inventory (SAI) at predetermined intervals post-administration. Data analysis focused on exploring associations between COMT gene variants and outcomes related to pain perception and anxiety during labor.</p> Results <p>Of the 53 participants, 35 were homozygous for the wild-type genotype (Val/Val). Approximately 33.9% displayed COMT gene polymorphisms: 14 women were heterozygous (Met/Val) and 4 were homozygous for the Met allele (Met/Met). Women with the Met/Met and Met/Val genotypes reported significantly higher scores on the State Anxiety Inventory (SAI) and Visual Analog Scale (VAS) compared to those with the Val/Val genotype (<i>p</i> &lt; 0.005). These women also required more supplementary analgesia during labor.</p> Conclusion <p>The presence of the Val158Met mutation in the COMT gene correlates with increased labor anxiety and reduced effectiveness of analgesia in pregnant women. Understanding the genetic factors influencing pain perception could improve analgesic strategies tailored to specific genetic profiles, potentially promoting higher rates of vaginal deliveries and better birth experiences for women. Further research into genetic markers of labor analgesia is crucial for refining pain management approaches in obstetrics.</p>

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The Role of Catechol-O-Methyl-Transferase Gene Variants in Modulating Labor Analgesia and Anxiety—A Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2026年5月5日

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  • Vinithira Sri G V,
  • Shreedevi Kori,
  • Shivanand L. Karigar,
  • Gurushantappa S. Kadakol,
  • Rajasri Yaliwal,
  • Neelamma Patil,
  • Aruna Biradar

摘要

Background

Women experiencing labor pain undergo significant psychological and physiological challenges, often leading to increased rates of cesarean sections.

Epidural analgesia has proven effective in managing labor pain, but its efficacy varies among individuals, partly due to genetic differences, including variations in the COMT gene, which influences pain perception pathways.

Methodology

Fifty-three hospitalized patients provided informed consent to participate in this study. Peripheral venous blood samples were collected in EDTA tubes for DNA isolation and Polymerase Chain Reaction (PCR) analysis to investigate COMT gene polymorphisms. Epidural analgesia (Fentanyl with Ropivacaine) was administered upon reaching regular uterine contractions and cervical dilation of 4–5 cm. Pain and anxiety levels were assessed using the Visual Analog Scale (VAS) and State Anxiety Inventory (SAI) at predetermined intervals post-administration. Data analysis focused on exploring associations between COMT gene variants and outcomes related to pain perception and anxiety during labor.

Results

Of the 53 participants, 35 were homozygous for the wild-type genotype (Val/Val). Approximately 33.9% displayed COMT gene polymorphisms: 14 women were heterozygous (Met/Val) and 4 were homozygous for the Met allele (Met/Met). Women with the Met/Met and Met/Val genotypes reported significantly higher scores on the State Anxiety Inventory (SAI) and Visual Analog Scale (VAS) compared to those with the Val/Val genotype (p < 0.005). These women also required more supplementary analgesia during labor.

Conclusion

The presence of the Val158Met mutation in the COMT gene correlates with increased labor anxiety and reduced effectiveness of analgesia in pregnant women. Understanding the genetic factors influencing pain perception could improve analgesic strategies tailored to specific genetic profiles, potentially promoting higher rates of vaginal deliveries and better birth experiences for women. Further research into genetic markers of labor analgesia is crucial for refining pain management approaches in obstetrics.