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Objectives <p>This study aimed to analyze the clinicopathological profile of primary epithelial ovarian cancer (EOC), evaluate estrogen (ER) and progesterone receptor (PR) expression, and assess their prognostic significance.</p> Methods <p>In this prospective study, patients with primary EOC who underwent surgery over two years were included. Clinical and pathological data were collected. Tissue microarrays (TMA) were constructed and stained for ER and PR expression. Patients were followed for disease recurrence and survival.</p> Results <p>A total of 336 patients with EOC underwent surgery. TMAs were successfully constructed for 150 patients, and follow-up data were available for 63 of them to calculate disease-free survival (DFS) and overall survival (OS). Among all patients, 53% underwent primary cytoreductive surgery, 37% received neoadjuvant chemotherapy (NACT) followed by interval surgery, and 9.9% were referred after prior surgery elsewhere. Serous carcinoma was the most common histological type (82%), followed by mucinous (20.6%), endometrioid (2.7%), and clear cell carcinoma (0.6%). ER and PR positivity in high-grade serous carcinoma (HGSC) was 91% and 50.8%, respectively, and was not significantly affected by NACT. Most endometrioid carcinomas (87.5%) were ER/PR positive, while clear cell and undifferentiated carcinomas were negative. ER and PR expression varied significantly among histological types (p = 0.004 and 0.012). However, no association was found between ER/PR expression and patient age, stage, grade, DFS, or OS.</p> Conclusion <p>ER/PR expression differs significantly across histological subtypes of EOC. However, their expression was not associated with survival outcomes.</p>

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Hormone Receptor Expression of Primary Epithelial Ovarian Neoplasms and Their Implications on Oncological Outcomes – Study From a Regional Cancer Center

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Arpitha Anantharaju,
  • Pratap Upadhya,
  • Kaarthiga Ramalingam Gopinath,
  • V. R. Pallavi,
  • C. Premalata,
  • U. D. Bafna

摘要

Objectives

This study aimed to analyze the clinicopathological profile of primary epithelial ovarian cancer (EOC), evaluate estrogen (ER) and progesterone receptor (PR) expression, and assess their prognostic significance.

Methods

In this prospective study, patients with primary EOC who underwent surgery over two years were included. Clinical and pathological data were collected. Tissue microarrays (TMA) were constructed and stained for ER and PR expression. Patients were followed for disease recurrence and survival.

Results

A total of 336 patients with EOC underwent surgery. TMAs were successfully constructed for 150 patients, and follow-up data were available for 63 of them to calculate disease-free survival (DFS) and overall survival (OS). Among all patients, 53% underwent primary cytoreductive surgery, 37% received neoadjuvant chemotherapy (NACT) followed by interval surgery, and 9.9% were referred after prior surgery elsewhere. Serous carcinoma was the most common histological type (82%), followed by mucinous (20.6%), endometrioid (2.7%), and clear cell carcinoma (0.6%). ER and PR positivity in high-grade serous carcinoma (HGSC) was 91% and 50.8%, respectively, and was not significantly affected by NACT. Most endometrioid carcinomas (87.5%) were ER/PR positive, while clear cell and undifferentiated carcinomas were negative. ER and PR expression varied significantly among histological types (p = 0.004 and 0.012). However, no association was found between ER/PR expression and patient age, stage, grade, DFS, or OS.

Conclusion

ER/PR expression differs significantly across histological subtypes of EOC. However, their expression was not associated with survival outcomes.