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Objective <p>To explore the effect of preoperative conization on the prognosis of patients with stage IB1 (FIGO 2018) cervical cancer and to compare the prognosis between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) following conization.</p> Methods <p>This multicentre, retrospective, case-paired cohort study compared the 5-year overall survival (OS) and disease-free survival (DFS) between the conization group and the non-conization group under the condition of propensity score matching. Further subgroup analysis was conducted to compare OS and DFS between laparoscopic surgery and abdominal surgery after conization.</p> Results <p>A total of 1319 patients with stage IB1 cervical cancer were included in this study, and there was no significant difference in oncological prognosis between the conization group (<i>n</i> = 383) and the non-conization group (<i>n</i> = 936) (OS: 94.3% versus 98.0%, <i>P</i> = 0.238; DFS: 93.1% versus 94.0%, <i>P</i> = 0.788). There was no significant difference in oncological prognosis between the conization group (<i>n</i> = 278) and the non-conization group (<i>n</i> = 502) after 1:2 propensity score matching (OS: 93.6% versus 97.3%, <i>P</i> = 0.688; DFS: 91.3% versus 92.9%, <i>P</i> = 0.968). Further subgroup analysis revealed that there was no significant difference in 5-year OS and DFS between LRH group and ARH group before and after 1:1 propensity score matching in patients who underwent conization.</p> Conclusions <p>Preoperative conization does not affect the oncological prognosis of patients with stage IB1 cervical cancer, and there is no significant difference in oncological prognosis between laparoscopic surgery and laparotomy following conization.</p>

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Effect of Preoperative Cervical Conization Before Hysterectomy on Survival and Recurrence in Patients with Stage IB1 (FIGO 2018) Cervical Cancer: A Chinese Multicentre Study

  • 期刊论文

  • 发表日期：

    2026年5月23日

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  • Haixia Jiang,
  • Cong Liang,
  • Lixin Sun,
  • Shan Kang,
  • Zhumei Cui,
  • Xiaonong Bin,
  • Ping Liu,
  • Chunlin Chen

摘要

Objective

To explore the effect of preoperative conization on the prognosis of patients with stage IB1 (FIGO 2018) cervical cancer and to compare the prognosis between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) following conization.

Methods

This multicentre, retrospective, case-paired cohort study compared the 5-year overall survival (OS) and disease-free survival (DFS) between the conization group and the non-conization group under the condition of propensity score matching. Further subgroup analysis was conducted to compare OS and DFS between laparoscopic surgery and abdominal surgery after conization.

Results

A total of 1319 patients with stage IB1 cervical cancer were included in this study, and there was no significant difference in oncological prognosis between the conization group (n = 383) and the non-conization group (n = 936) (OS: 94.3% versus 98.0%, P = 0.238; DFS: 93.1% versus 94.0%, P = 0.788). There was no significant difference in oncological prognosis between the conization group (n = 278) and the non-conization group (n = 502) after 1:2 propensity score matching (OS: 93.6% versus 97.3%, P = 0.688; DFS: 91.3% versus 92.9%, P = 0.968). Further subgroup analysis revealed that there was no significant difference in 5-year OS and DFS between LRH group and ARH group before and after 1:1 propensity score matching in patients who underwent conization.

Conclusions

Preoperative conization does not affect the oncological prognosis of patients with stage IB1 cervical cancer, and there is no significant difference in oncological prognosis between laparoscopic surgery and laparotomy following conization.