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Purpose <p>To explore how gestational diabetes mellitus (GDM) influences maternal cardiac acclimatization to the increasing cardiovascular demands of pregnancy.</p> Methods <p>This is a prospective, comparative study involving women from Eastern India, suffering from GDM attending Antenatal OPD at IPGMER, Kolkata. Consecutive 239 GDM women recruited, diagnosed using Diabetes in Pregnancy Study group India (DIPSI) criteria, and were compared with age matched non-GDM controls. Demographic, clinical, biochemical, cardiological parameters were analyzed, using SPSS 27.0.</p> Results <p>Compared with women in the control group, women with GDM were older, had higher body mass index (BMI) at booking, comparatively belong to higher socioeconomic status, more likely to have pregnancy complications, increased cesarean section rate, delivered babies with higher birth weight and required more NICU support. There was no significant difference in abnormal ECG findings. Women with GDM had a greater left atrial dimension, LV posterior wall thickness and LV mass. But, left ventricular (LV) diastolic dimension was decreased. The women with GDM had lower values of the early diastolic annular velocity (E′), lower GLS of the left ventricle than those in the control group. The LV ejection fraction was similar in both the groups. NT-pro BNP levels showed no statistical difference for 3rd trimesters, but in post-delivery, the difference was statistically significant.</p> Conclusions <p>Patients with GDM have subclinical alterations in cardiac dimensions and subtle differences in diastolic and systolic left ventricular function compared to controls, at late 3rd trimester and after delivery. This may be the beginning of future cardiac morbidity.</p>

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Assessment of Maternal Cardiac Adaptations in Women with Gestational Diabetes Mellitus

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Raghunath Bhattacharyya,
  • Ankita Soni,
  • Gouranga Sarkar,
  • Debmalya Maity,
  • Saumen Mandal,
  • Sayantanee Sengupta,
  • Goutam Datta,
  • Chaitali Datta Ray

摘要

Purpose

To explore how gestational diabetes mellitus (GDM) influences maternal cardiac acclimatization to the increasing cardiovascular demands of pregnancy.

Methods

This is a prospective, comparative study involving women from Eastern India, suffering from GDM attending Antenatal OPD at IPGMER, Kolkata. Consecutive 239 GDM women recruited, diagnosed using Diabetes in Pregnancy Study group India (DIPSI) criteria, and were compared with age matched non-GDM controls. Demographic, clinical, biochemical, cardiological parameters were analyzed, using SPSS 27.0.

Results

Compared with women in the control group, women with GDM were older, had higher body mass index (BMI) at booking, comparatively belong to higher socioeconomic status, more likely to have pregnancy complications, increased cesarean section rate, delivered babies with higher birth weight and required more NICU support. There was no significant difference in abnormal ECG findings. Women with GDM had a greater left atrial dimension, LV posterior wall thickness and LV mass. But, left ventricular (LV) diastolic dimension was decreased. The women with GDM had lower values of the early diastolic annular velocity (E′), lower GLS of the left ventricle than those in the control group. The LV ejection fraction was similar in both the groups. NT-pro BNP levels showed no statistical difference for 3rd trimesters, but in post-delivery, the difference was statistically significant.

Conclusions

Patients with GDM have subclinical alterations in cardiac dimensions and subtle differences in diastolic and systolic left ventricular function compared to controls, at late 3rd trimester and after delivery. This may be the beginning of future cardiac morbidity.