Scholarlink

Background/Purpose <p>Mucinous ovarian carcinoma (MOC) is often diagnosed at an early stage with a low prevalence of nodal metastasis. The benefit of routine lymphadenectomy (LND) in this setting remains uncertain. This study evaluated whether lymphadenectomy confers improved survival outcomes in women with early-stage MOC.</p> Methods <p>We conducted a retrospective cohort study of women with stage I–II MOC who underwent primary surgery at a tertiary university-affiliated hospital between 2009 and 2016. Patients were categorized into LND and non-LND groups. The primary endpoint was overall survival (OS), and the secondary endpoint was progression-free survival (PFS). Survival was estimated by Kaplan–Meier analysis with log-rank testing, and Cox proportional hazards models were applied to identify prognostic factors.</p> Results <p>Of 256 patients screened, 121 were eligible (75 LND, 46 non-LND). No nodal metastases were identified in the LND group. Median operative time was significantly longer with LND (240 vs. 195&#xa0;min, <i>P</i> &lt; 0.001). Postoperative complications occurred exclusively in the LND group (lymphocyst, small bowel serosal injury). At a median follow-up of 99.7&#xa0;months, 5&#xa0;year OS was 97.3% in the LND group versus 91.3% in the non-LND group, an absolute difference of 6% that did not reach statistical significance. LND was not associated with improved OS or PFS in univariable or multivariable analyses.</p> Conclusion <p>Routine lymphadenectomy does not improve survival in early-stage MOC but increases operative morbidity. Given the excellent prognosis of early-stage disease and the low risk of nodal involvement, omission of lymphadenectomy may be appropriate, particularly in stage I patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Survival Outcomes after Lymphadenectomy in Early-Stage Mucinous Ovarian Cancer: An Asian Institutional Experience

  • 期刊论文

  • 发表日期：

    2026年1月21日

查看全文
  • Nungrutai Saeaib,
  • Krittanai Kuntheekan,
  • Rakchai Buhachat,
  • Ekasak Thiangphak

摘要

Background/Purpose

Mucinous ovarian carcinoma (MOC) is often diagnosed at an early stage with a low prevalence of nodal metastasis. The benefit of routine lymphadenectomy (LND) in this setting remains uncertain. This study evaluated whether lymphadenectomy confers improved survival outcomes in women with early-stage MOC.

Methods

We conducted a retrospective cohort study of women with stage I–II MOC who underwent primary surgery at a tertiary university-affiliated hospital between 2009 and 2016. Patients were categorized into LND and non-LND groups. The primary endpoint was overall survival (OS), and the secondary endpoint was progression-free survival (PFS). Survival was estimated by Kaplan–Meier analysis with log-rank testing, and Cox proportional hazards models were applied to identify prognostic factors.

Results

Of 256 patients screened, 121 were eligible (75 LND, 46 non-LND). No nodal metastases were identified in the LND group. Median operative time was significantly longer with LND (240 vs. 195 min, P < 0.001). Postoperative complications occurred exclusively in the LND group (lymphocyst, small bowel serosal injury). At a median follow-up of 99.7 months, 5 year OS was 97.3% in the LND group versus 91.3% in the non-LND group, an absolute difference of 6% that did not reach statistical significance. LND was not associated with improved OS or PFS in univariable or multivariable analyses.

Conclusion

Routine lymphadenectomy does not improve survival in early-stage MOC but increases operative morbidity. Given the excellent prognosis of early-stage disease and the low risk of nodal involvement, omission of lymphadenectomy may be appropriate, particularly in stage I patients.