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Aim <p>To study the role of quantitative CEUS parameters in predicting neo-angiogenesis in carcinoma cervix by correlating them with MVD.</p> Methods <p>Patients with biopsy-proven carcinoma cervix were included, and CEUS was done. Quantitative parameters [mean transit time (MTT), time to peak (TTP), peak (target), area under the curve (AUC)] and qualitative parameters [enhancement time, enhancement extent and contrast distribution] were correlated with histopathology-based MVD, grade, and FIGO stage of the tumour.</p> Results <p>There was a strong positive correlation between Peak (Target) and MVD (correlation coefficient (rho) = 0.83, <i>p</i> value &lt; 0.001). There was a moderate correlation between TTP, AUC and MVD (rho 0.42 and 0.34). However, there was no correlation between MTT and MVD (rho 0.29). There was no significant association between CEUS parameters and the grade/FIGO stage of cervical carcinoma.</p> Conclusions <p>CEUS is an acceptable non-invasive technique for evaluating tumour angiogenesis since the parameters correlate well with MVD. Hence, CEUS can predict the aggressiveness of cervical carcinoma, thereby guiding appropriate prognostication and management.</p> Key Message <p>Tumour angiogenesis is an independent critical prognostic factor in determining recurrence and poor outcomes in carcinoma of the cervix. There are numerous biomarkers to quantify angiogenesis, such as vascular endothelial growth factor, essential fibroblast growth factor, and MVD. Their assessment requires histopathological examination, and the results can be variable due to intra-tumoral heterogeneity. CEUS is a non-invasive technique that can assess tumour microcirculation's spatial and temporal variations.</p>

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Contrast-Enhanced Ultrasound Parameters in Prediction of Intra-tumoral Angiogenesis in Carcinoma Cervix

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Arthi Kumari Yadav,
  • Neha Bagri,
  • Ritu Misra,
  • Saritha Shamsunder,
  • Sachin Kolte

摘要

Aim

To study the role of quantitative CEUS parameters in predicting neo-angiogenesis in carcinoma cervix by correlating them with MVD.

Methods

Patients with biopsy-proven carcinoma cervix were included, and CEUS was done. Quantitative parameters [mean transit time (MTT), time to peak (TTP), peak (target), area under the curve (AUC)] and qualitative parameters [enhancement time, enhancement extent and contrast distribution] were correlated with histopathology-based MVD, grade, and FIGO stage of the tumour.

Results

There was a strong positive correlation between Peak (Target) and MVD (correlation coefficient (rho) = 0.83, p value < 0.001). There was a moderate correlation between TTP, AUC and MVD (rho 0.42 and 0.34). However, there was no correlation between MTT and MVD (rho 0.29). There was no significant association between CEUS parameters and the grade/FIGO stage of cervical carcinoma.

Conclusions

CEUS is an acceptable non-invasive technique for evaluating tumour angiogenesis since the parameters correlate well with MVD. Hence, CEUS can predict the aggressiveness of cervical carcinoma, thereby guiding appropriate prognostication and management.

Key Message

Tumour angiogenesis is an independent critical prognostic factor in determining recurrence and poor outcomes in carcinoma of the cervix. There are numerous biomarkers to quantify angiogenesis, such as vascular endothelial growth factor, essential fibroblast growth factor, and MVD. Their assessment requires histopathological examination, and the results can be variable due to intra-tumoral heterogeneity. CEUS is a non-invasive technique that can assess tumour microcirculation's spatial and temporal variations.