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Background <p>Male breast cancer (MBC) is a rare malignancy, accounting for less than 1% of all breast cancer cases. Due to its rarity, region-specific clinical data are limited, especially in low- and middle-income countries.</p> Aim <p>To evaluate the socio-demographic characteristics, clinical features, and oncological outcomes of MBC patients treated at XXX between January 2010 and December 2022.</p> Methods <p>A retrospective record review was conducted among 57 male breast cancer patients registered at XXX. Data were extracted from institutional records, including demographic details, staging, histopathology, receptor status, treatment received, and survival outcomes. Kaplan–Meier method was used for survival analysis.</p> Results <p>The median age at diagnosis was 65&#xa0;years, with the majority presenting with Stage II or III disease. Invasive ductal carcinoma was the predominant histology (86%). Hormone receptor positivity (ER/PR +) was observed in over 75% of cases. Modified radical mastectomy was the primary surgical approach. The five-year overall survival was 53.7%.Luminal type B had poor survival outcomes compared to Luminal type A.</p> Conclusion <p>MBC at our centre&#xa0;was characterized by late-stage presentation and high hormone receptor positivity. Despite limited awareness, MBC patients at our center achieved favorable five-year outcomes with standard treatment protocols. Greater awareness, early detection, and integration of genetic counseling are essential to improving prognosis in male breast cancer.</p>

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Male Breast Cancer in India: Socio-Demographic Characteristics, Clinical Presentation, and Survival Outcomes—Descriptive Study

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Saina Sunilkumar,
  • Karthickeyan Duraisamy,
  • Thaddeus Alfonso,
  • T. Bindu,
  • Mohandoss Murugesan,
  • Satheesan Balasubramanian

摘要

Background

Male breast cancer (MBC) is a rare malignancy, accounting for less than 1% of all breast cancer cases. Due to its rarity, region-specific clinical data are limited, especially in low- and middle-income countries.

Aim

To evaluate the socio-demographic characteristics, clinical features, and oncological outcomes of MBC patients treated at XXX between January 2010 and December 2022.

Methods

A retrospective record review was conducted among 57 male breast cancer patients registered at XXX. Data were extracted from institutional records, including demographic details, staging, histopathology, receptor status, treatment received, and survival outcomes. Kaplan–Meier method was used for survival analysis.

Results

The median age at diagnosis was 65 years, with the majority presenting with Stage II or III disease. Invasive ductal carcinoma was the predominant histology (86%). Hormone receptor positivity (ER/PR +) was observed in over 75% of cases. Modified radical mastectomy was the primary surgical approach. The five-year overall survival was 53.7%.Luminal type B had poor survival outcomes compared to Luminal type A.

Conclusion

MBC at our centre was characterized by late-stage presentation and high hormone receptor positivity. Despite limited awareness, MBC patients at our center achieved favorable five-year outcomes with standard treatment protocols. Greater awareness, early detection, and integration of genetic counseling are essential to improving prognosis in male breast cancer.