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Objectives <p>To compare telomere length, <i>hTERT</i> expression, and telomerase activity in maternal blood of patients with spontaneous preterm birth (sPTB) and term birth (TB).</p> Materials and Methods <p>One hundred and twenty participants were enrolled in this study. 60 cases of sPTB and 60 healthy controls. Whole blood was used for the estimation of Telomere Length (TL), hTERT expression, and PBMC which were used for the estimation of telomerase activity. TL and hTERT expression were measured via real-time PCR, and telomerase activity was measured using commercially available research kit.</p> Results <p>The mean (SD) TL was 239.65 (160.2) in the sPTB group and 395.18 (170.4) in the TB group (<i>p</i> = 0.000). There was no difference in hTERT mRNA expression and telomerase activity between sPTB and TB.</p> Conclusion <p>sPTB is associated with shorter TL as compared to TB, even though there was no difference in telomerase activity. Therefore, shorter maternal telomere length has the potential to be a marker of sPTB.</p> <p><b>What does this study add to the clinical work</b>: Women with inherent shorter TL are more prone to sPTB compared to healthy controls. Maternal TL could serve as a predictive marker of sPTB.</p>

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Shorter Telomere Length in Maternal White Blood Cells is Associated with Spontaneous Preterm Birth

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Rajarshi Kar,
  • Mohit Mehndiratta,
  • Amita Suneja,
  • Edelbert Anthonio Almeida,
  • Rupa Kumari,
  • Bindiya Gupta,
  • Seema Garg

摘要

Objectives

To compare telomere length, hTERT expression, and telomerase activity in maternal blood of patients with spontaneous preterm birth (sPTB) and term birth (TB).

Materials and Methods

One hundred and twenty participants were enrolled in this study. 60 cases of sPTB and 60 healthy controls. Whole blood was used for the estimation of Telomere Length (TL), hTERT expression, and PBMC which were used for the estimation of telomerase activity. TL and hTERT expression were measured via real-time PCR, and telomerase activity was measured using commercially available research kit.

Results

The mean (SD) TL was 239.65 (160.2) in the sPTB group and 395.18 (170.4) in the TB group (p = 0.000). There was no difference in hTERT mRNA expression and telomerase activity between sPTB and TB.

Conclusion

sPTB is associated with shorter TL as compared to TB, even though there was no difference in telomerase activity. Therefore, shorter maternal telomere length has the potential to be a marker of sPTB.

What does this study add to the clinical work: Women with inherent shorter TL are more prone to sPTB compared to healthy controls. Maternal TL could serve as a predictive marker of sPTB.