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Background <p>Prelabor rupture of membranes is one prevalent condition linked to significant maternal as well as perinatal morbidity. A quick or reliable test for the diagnosis is essential to apply suitable measures for improving perinatal outcomes.</p> Aim <p>To evaluate urea and creatinine in the vaginal fluid as markers of preterm prelabor rupture of membranes (PPROM) and to determine their diagnostic cutoff values based on the findings.</p> Methods <p>One prospective case–control research has been performed on 150 women with gestational age 28–36&#xa0;weeks 6&#xa0;days. Pregnant women have been classified into 3 groups of 50 women each. Group A included cases, group B included suspects, and group C was control group. Analysis of data has been performed using ANOVA and Chi-square test.</p> Results <p>Mean vaginal fluid urea levels in groups A, B and C have been 9.16 ± 6.01&#xa0;mg/dl, 2.06 ± 0.82&#xa0;mg/dl and 0.75 ± 0.48&#xa0;mg/dl and mean creatinine values have been 0.52 ± 0.47&#xa0;mg/dl, 0.13 ± 0.08&#xa0;mg/dl, 0.18 ± 0.27&#xa0;mg/dl, respectively, where difference has been statistically significant (<i>p</i> &lt; 0.001). Optimum cutoff value for vaginal fluid urea in Group A and B was ≥ 2.5&#xa0;mg/dl and ≥ 1.5&#xa0;mg/dl with sensitivity and specificity of 98%, 100% and 82%, 96%, respectively. The cutoff values of creatinine for Group A were ≥ 0.2&#xa0;mg/dl and for Group B were ≥ 0.1&#xa0;mg/dl, with sensitivity and specificity of 88%, 80% and 46%, 60%, respectively.</p> Conclusion <p>Detection of urea and creatinine in vaginal fluid is an easy, safe, economic technique for diagnosing PPROM. Urea is a better predictor having high sensitivity and specificity.</p>

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Estimation of urea and creatinine in vaginal fluid in preterm prelabour rupture of membranes

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Heena Ladher,
  • Sunil Kumar Juneja,
  • Shweta Gupta,
  • Navjot Bajwa,
  • Amandeep Kaur,
  • Prannav Jain

摘要

Background

Prelabor rupture of membranes is one prevalent condition linked to significant maternal as well as perinatal morbidity. A quick or reliable test for the diagnosis is essential to apply suitable measures for improving perinatal outcomes.

Aim

To evaluate urea and creatinine in the vaginal fluid as markers of preterm prelabor rupture of membranes (PPROM) and to determine their diagnostic cutoff values based on the findings.

Methods

One prospective case–control research has been performed on 150 women with gestational age 28–36 weeks 6 days. Pregnant women have been classified into 3 groups of 50 women each. Group A included cases, group B included suspects, and group C was control group. Analysis of data has been performed using ANOVA and Chi-square test.

Results

Mean vaginal fluid urea levels in groups A, B and C have been 9.16 ± 6.01 mg/dl, 2.06 ± 0.82 mg/dl and 0.75 ± 0.48 mg/dl and mean creatinine values have been 0.52 ± 0.47 mg/dl, 0.13 ± 0.08 mg/dl, 0.18 ± 0.27 mg/dl, respectively, where difference has been statistically significant (p < 0.001). Optimum cutoff value for vaginal fluid urea in Group A and B was ≥ 2.5 mg/dl and ≥ 1.5 mg/dl with sensitivity and specificity of 98%, 100% and 82%, 96%, respectively. The cutoff values of creatinine for Group A were ≥ 0.2 mg/dl and for Group B were ≥ 0.1 mg/dl, with sensitivity and specificity of 88%, 80% and 46%, 60%, respectively.

Conclusion

Detection of urea and creatinine in vaginal fluid is an easy, safe, economic technique for diagnosing PPROM. Urea is a better predictor having high sensitivity and specificity.