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Background <p>Beta Thalassemia Trait (BTT) is a significant public health concern, particularly in India, due to its high prevalence. Early detection through cost-effective screening methods is crucial, especially in low-resource settings where High-Performance Liquid Chromatography (HPLC) is not readily available. Objective.</p> <p>This study aimed to evaluate the diagnostic reliability of hematological indices in detecting BTT among pregnant women, using HPLC as the gold standard.</p> Materials and Methods <p>A retrospective study was conducted at a tertiary care center in eastern India, analyzing 3,249 pregnant women with hemoglobin levels 3.5%), and the sensitivity, specificity, PPV, and NPV of hematological indices (Mentzer Index, RDW Index, Shine &amp; Lal Index, Srivastav Index) were assessed.</p> Results <p>Among 103 confirmed BTT cases, the Shine &amp; Lal Index had the highest sensitivity (99.01%) and NPV (99.5%), correctly identifying 102 cases. Mentzer’s Index detected 24 cases (23.3%), Srivastav Index 21 (20.38%), and RDW Index 33 (32.03%). While all indices had high specificity (&gt; 99%), Shine &amp; Lal Index had the highest overall accuracy (74%).</p> Conclusion <p>The Shine &amp; Lal Index is a reliable, cost-effective screening tool for BTT in pregnant women, particularly in low-resource settings where HPLC is unavailable. Early detection enables timely genetic counseling and intervention.</p>

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Diagnostic Efficacy of Hematological Indices in Screening of Beta Thalassemia trait in Pregnancy in Low Resource Settings: A Retrospective Analysis in a Tertiary Care Center of Eastern India

  • 期刊论文

  • 发表日期：

    2025年11月28日

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  • Madhulima Saha,
  • Alpana Gupta,
  • Priyanka Mishra,
  • Manisha Agarwal,
  • Rony Chakravarty,
  • Prayas Roy,
  • Lavanya Tutika,
  • Rubina Siraj

摘要

Background

Beta Thalassemia Trait (BTT) is a significant public health concern, particularly in India, due to its high prevalence. Early detection through cost-effective screening methods is crucial, especially in low-resource settings where High-Performance Liquid Chromatography (HPLC) is not readily available. Objective.

This study aimed to evaluate the diagnostic reliability of hematological indices in detecting BTT among pregnant women, using HPLC as the gold standard.

Materials and Methods

A retrospective study was conducted at a tertiary care center in eastern India, analyzing 3,249 pregnant women with hemoglobin levels 3.5%), and the sensitivity, specificity, PPV, and NPV of hematological indices (Mentzer Index, RDW Index, Shine & Lal Index, Srivastav Index) were assessed.

Results

Among 103 confirmed BTT cases, the Shine & Lal Index had the highest sensitivity (99.01%) and NPV (99.5%), correctly identifying 102 cases. Mentzer’s Index detected 24 cases (23.3%), Srivastav Index 21 (20.38%), and RDW Index 33 (32.03%). While all indices had high specificity (> 99%), Shine & Lal Index had the highest overall accuracy (74%).

Conclusion

The Shine & Lal Index is a reliable, cost-effective screening tool for BTT in pregnant women, particularly in low-resource settings where HPLC is unavailable. Early detection enables timely genetic counseling and intervention.