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Background <p>Maternal sepsis is the third most frequent cause of direct maternal deaths. Failure to recognize sepsis early is a significant cause of preventable morbidity and mortality.</p> Aim <p>Our study aimed to assess the prevalence, clinical spectrum and residual morbidity amongst women experiencing near-miss morbidity due to sepsis.</p> Methods <p>A prospective observational study was conducted from December 2018 to November 2020 at PGIMER, Chandigarh, a tertiary care hospital in north India after ethical approval.</p> <p>Critically ill pregnant, labouring, post-partum/post-abortal women within 42&#xa0;days, admitted to index institution premises with suspected or diagnosed sepsis fulfilling near-miss criteria according to GOI and/or WHO, were included. Data were collected by medical doctors who were hired for the research study. The clinical presentation, initial management, hospital course and residual morbidity at the time of discharge were noted.</p> Results <p>Sepsis was the primary cause of near-miss morbidity in 54 women out of the total 426 near-miss cases, accounting to 12.7%. Out of these, 46 (85.2%) cases were referred from peripheral health facilities. There were 13 (24.1%) antenatal, 31 (57.4%) post-partum and 10 (18.5%) in post-abortion period. Direct obstetric sepsis was identified in 33 (61.1%), indirect in 8 (14.8%), while focus remained unidentified in 13 (24.1%). Peritonitis was the most common diagnosis at admission in 27 (50%). Immediate surgical intervention was required in 30 (55%) of the cases. Around 69% of cases had residual morbidity at discharge.</p> Conclusion <p>Index study shows that direct obstetrical sepsis is more common amongst post-partum women and medical comorbidities are importantly associated with sepsis.</p>

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Analysis of Sepsis-Related Maternal Near-Miss Morbidity in a Tertiary Care Hospital: a Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2025年9月19日

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  • Aashima Arora,
  • Geetika Thakur,
  • Vanita Jain,
  • Pooja Sikka,
  • Aruna Singh

摘要

Background

Maternal sepsis is the third most frequent cause of direct maternal deaths. Failure to recognize sepsis early is a significant cause of preventable morbidity and mortality.

Aim

Our study aimed to assess the prevalence, clinical spectrum and residual morbidity amongst women experiencing near-miss morbidity due to sepsis.

Methods

A prospective observational study was conducted from December 2018 to November 2020 at PGIMER, Chandigarh, a tertiary care hospital in north India after ethical approval.

Critically ill pregnant, labouring, post-partum/post-abortal women within 42 days, admitted to index institution premises with suspected or diagnosed sepsis fulfilling near-miss criteria according to GOI and/or WHO, were included. Data were collected by medical doctors who were hired for the research study. The clinical presentation, initial management, hospital course and residual morbidity at the time of discharge were noted.

Results

Sepsis was the primary cause of near-miss morbidity in 54 women out of the total 426 near-miss cases, accounting to 12.7%. Out of these, 46 (85.2%) cases were referred from peripheral health facilities. There were 13 (24.1%) antenatal, 31 (57.4%) post-partum and 10 (18.5%) in post-abortion period. Direct obstetric sepsis was identified in 33 (61.1%), indirect in 8 (14.8%), while focus remained unidentified in 13 (24.1%). Peritonitis was the most common diagnosis at admission in 27 (50%). Immediate surgical intervention was required in 30 (55%) of the cases. Around 69% of cases had residual morbidity at discharge.

Conclusion

Index study shows that direct obstetrical sepsis is more common amongst post-partum women and medical comorbidities are importantly associated with sepsis.