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Purpose <p>To assess the causes and clinical outcomes of maternal near-misses and mortality associated with hematologic diseases.</p> Methods <p>We retrospectively reviewed the medical records from women who experienced maternal near-misses or mortality attributed to hematological diseases during pregnancy or within 42&#xa0;days of pregnancy termination, following the World Health Organization criteria, at a single quaternary referral center in Southern Thailand, from 2006 to 2021.</p> Results <p>A total of 109 cases were analyzed, including five maternal deaths and 104 near-miss cases related to hematologic diseases. The median (min–max) maternal age was 29 (14–43) years, with 57.8% of the women being multiparous. The most common hematologic diseases were immune thrombocytopenia (68.8%), acute leukemia (6.4%), and aplastic anemia (6.4%). Of these, 48.6% were diagnosed before pregnancy and 57.8% exhibited a platelet count &lt; 50 × 10<sup>9</sup>/L during the intrapartum period. Acute leukemia was the leading cause of death (3/5). Severe maternal outcomes in cases of immune thrombocytopenia were more frequently observed in women with platelet counts &lt; 50 × 10<sup>9</sup>/L.</p> Conclusion <p>The primary hematologic diseases causing maternal near-miss and mortality were immune thrombocytopenia, acute leukemia, and aplastic anemia. Acute leukemia was the leading cause of death.</p>

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Analysis of Maternal Near-miss and Mortality with Hematologic Diseases in a Single Quaternary Referral Center in Southern Thailand

  • 期刊论文

  • 发表日期：

    2025年4月11日

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  • Krantarat Peeyananjarassri,
  • Chitkasaem Suwanrath,
  • Ninizna Ratipann,
  • Natthicha Chainarong,
  • Sathana Boonyapipat,
  • Sutham Pinjaroen

摘要

Purpose

To assess the causes and clinical outcomes of maternal near-misses and mortality associated with hematologic diseases.

Methods

We retrospectively reviewed the medical records from women who experienced maternal near-misses or mortality attributed to hematological diseases during pregnancy or within 42 days of pregnancy termination, following the World Health Organization criteria, at a single quaternary referral center in Southern Thailand, from 2006 to 2021.

Results

A total of 109 cases were analyzed, including five maternal deaths and 104 near-miss cases related to hematologic diseases. The median (min–max) maternal age was 29 (14–43) years, with 57.8% of the women being multiparous. The most common hematologic diseases were immune thrombocytopenia (68.8%), acute leukemia (6.4%), and aplastic anemia (6.4%). Of these, 48.6% were diagnosed before pregnancy and 57.8% exhibited a platelet count < 50 × 109/L during the intrapartum period. Acute leukemia was the leading cause of death (3/5). Severe maternal outcomes in cases of immune thrombocytopenia were more frequently observed in women with platelet counts < 50 × 109/L.

Conclusion

The primary hematologic diseases causing maternal near-miss and mortality were immune thrombocytopenia, acute leukemia, and aplastic anemia. Acute leukemia was the leading cause of death.