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<p>Hybrid nanoparticles (HNPs) have high potential in various biomedical fields, such as drug delivery, bio-signal detection, and delivery systems, as they can simultaneously realize biocompatibility and functionalization based on the complex structure of organic and inorganic materials. Microfluidic technology was introduced to synthesize HNP precisely to regulate size, shape, and functionality uniformity. Case studies of on-chip HNP platforms are presented, including microfluidic vascular models, tumor microenvironments, and blood-brain barrier models that enable real-time analysis of nanoparticle dynamics, drug release kinetics, and cellular uptake efficiency in physiologically relevant contexts. The review comprehensively examines the microfluidic-based synthesis of HNPs with the recent trends and possibilities of on-chip bio-application technology. In addition, diagnostic platforms and biosensor technologies using HNPs as detection mediators are discussed as biomarker detection, multiple signal response, and real-time monitoring technologies based on high sensitivity and selectivity. Integrated cell chip-based platforms enable simultaneous HNP analysis, streamlined sample preparation, and long-term biological interaction modeling, critical capabilities for advancing precision medicine. Therefore, it suggests that these technologies develop into an integrated platform that can contribute to precision medicine, self-diagnosis, and customized treatment in the near future.</p>

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Advances in Hybrid Nanoparticle Synthesis Through Microfluidics for In-chip Biomedical Studies

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Jin Hee Park,
  • Chanmey Kong,
  • Bumjun Park,
  • Jungeun Ahn,
  • Vivek Kumar Gupta,
  • Pooyan Makvandi,
  • Yun Suk Huh,
  • Seongsoo Jang

摘要

Hybrid nanoparticles (HNPs) have high potential in various biomedical fields, such as drug delivery, bio-signal detection, and delivery systems, as they can simultaneously realize biocompatibility and functionalization based on the complex structure of organic and inorganic materials. Microfluidic technology was introduced to synthesize HNP precisely to regulate size, shape, and functionality uniformity. Case studies of on-chip HNP platforms are presented, including microfluidic vascular models, tumor microenvironments, and blood-brain barrier models that enable real-time analysis of nanoparticle dynamics, drug release kinetics, and cellular uptake efficiency in physiologically relevant contexts. The review comprehensively examines the microfluidic-based synthesis of HNPs with the recent trends and possibilities of on-chip bio-application technology. In addition, diagnostic platforms and biosensor technologies using HNPs as detection mediators are discussed as biomarker detection, multiple signal response, and real-time monitoring technologies based on high sensitivity and selectivity. Integrated cell chip-based platforms enable simultaneous HNP analysis, streamlined sample preparation, and long-term biological interaction modeling, critical capabilities for advancing precision medicine. Therefore, it suggests that these technologies develop into an integrated platform that can contribute to precision medicine, self-diagnosis, and customized treatment in the near future.