Scholarlink

<p>The present study investigated the protective effects of ferulic acid against behavioral and neurochemical alterations induced by early life stress (ELS) using a maternal separation model in mice. Swiss albino mouse pups were subjected to maternal separation from postnatal day 2 to 14. During adulthood, animals received ferulic acid (40 and 80&#xa0;mg/kg, p.o.) or fluoxetine (20&#xa0;mg/kg, p.o.) for 15 days. Behavioral assessments included the elevated plus maze, open field test, tail suspension test, and Morris water maze. Oxidative stress, inflammatory, cholinergic, monoaminergic, and neuroendocrine parameters were evaluated in the hippocampus and cerebral cortex. Maternal separation stress produced significant anxiety-like and depressive-like behaviors, impaired spatial learning and memory, elevated corticosterone levels, increased thiobarbituric acid reactive substances (TBARS), nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and acetylcholinesterase (AChE) activity, and decreased reduced glutathione (GSH), serotonin, and dopamine levels in both hippocampal and cortical brain regions. Ferulic acid treatment significantly attenuated behavioral deficits, reduced corticosterone concentrations, restored antioxidant status, suppressed inflammatory mediators, normalized AChE activity, and increased serotonin and dopamine levels. Correlation analysis revealed significant associations between behavioral performance and neurochemical alterations, indicating that improvements in cognitive and affective outcomes were accompanied by normalization of oxidative stress, neuroinflammatory, cholinergic, monoaminergic, and neuroendocrine disturbances. These findings demonstrate that ferulic acid attenuates the long-term behavioral and neurochemical consequences of ELS and support further investigation of its neuroprotective potential in stress-related neurobehavioral disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ferulic acid attenuates early life stress induced behavioral and neurochemical alterations via modulating HPA axis, oxidative stress, and NF-κB mediated neuroinflammation

  • 期刊论文

  • 发表日期：

    2026年7月21日

查看全文
  • Simran,
  • Varinder Singh,
  • Navjot Kanwar,
  • Manjinder Singh,
  • Tanveer Singh,
  • Thakur Gurjeet Singh,
  • Amarjot Kaur Grewal,
  • Sheikh F. Ahmad,
  • Haneen A. Al-Mazroua

摘要

The present study investigated the protective effects of ferulic acid against behavioral and neurochemical alterations induced by early life stress (ELS) using a maternal separation model in mice. Swiss albino mouse pups were subjected to maternal separation from postnatal day 2 to 14. During adulthood, animals received ferulic acid (40 and 80 mg/kg, p.o.) or fluoxetine (20 mg/kg, p.o.) for 15 days. Behavioral assessments included the elevated plus maze, open field test, tail suspension test, and Morris water maze. Oxidative stress, inflammatory, cholinergic, monoaminergic, and neuroendocrine parameters were evaluated in the hippocampus and cerebral cortex. Maternal separation stress produced significant anxiety-like and depressive-like behaviors, impaired spatial learning and memory, elevated corticosterone levels, increased thiobarbituric acid reactive substances (TBARS), nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and acetylcholinesterase (AChE) activity, and decreased reduced glutathione (GSH), serotonin, and dopamine levels in both hippocampal and cortical brain regions. Ferulic acid treatment significantly attenuated behavioral deficits, reduced corticosterone concentrations, restored antioxidant status, suppressed inflammatory mediators, normalized AChE activity, and increased serotonin and dopamine levels. Correlation analysis revealed significant associations between behavioral performance and neurochemical alterations, indicating that improvements in cognitive and affective outcomes were accompanied by normalization of oxidative stress, neuroinflammatory, cholinergic, monoaminergic, and neuroendocrine disturbances. These findings demonstrate that ferulic acid attenuates the long-term behavioral and neurochemical consequences of ELS and support further investigation of its neuroprotective potential in stress-related neurobehavioral disorders.