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<p>The current review critically discusses microbial laccase as an emerging green biocatalyst towards the sustainable degradation of xenobiotic pollutants. The review integrates current knowledge on laccase diversity, catalytic mechanisms, mediator systems, and emerging industrial applications. An illustrative computational case study of <i>Bacillus subtilis</i> laccase suggested potential interactions of conserved residues at the T1 copper site with substrates such as congo red, doxorubicin, and difenoconazole, indicating a possible role in substrate binding interactions. Global bibliometric analysis (2012–2025) summarizes global research trends and collaborations in laccase-mediated bioremediation research. This combination of experimental literature and bibliometric analysis aims to provide a comprehensive overview of current research directions and technological potential of laccases. The review also identifies key challenges associated with enzyme operational stability, production, and scalability. Future research developments should focus on integrating protein engineering, nanobiocatalysis, and AI-assisted process optimization to enhance the efficiency and scalability of laccase-based industrial applications within the circular bioeconomic framework.</p>

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Laccase as a green biocatalyst for xenobiotic degradation: integrative insights from molecular docking and bibliometric analysis

  • 期刊论文

  • 发表日期：

    2026年6月27日

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  • Shivangi Chamoli,
  • Ananta Gupta,
  • Ashutosh Pal,
  • Priyanka Negi,
  • Kanchan Karki,
  • Ambika Chamoli,
  • Ravendra Kumar,
  • Sunil Kumar Suman,
  • Piyush Kumar

摘要

The current review critically discusses microbial laccase as an emerging green biocatalyst towards the sustainable degradation of xenobiotic pollutants. The review integrates current knowledge on laccase diversity, catalytic mechanisms, mediator systems, and emerging industrial applications. An illustrative computational case study of Bacillus subtilis laccase suggested potential interactions of conserved residues at the T1 copper site with substrates such as congo red, doxorubicin, and difenoconazole, indicating a possible role in substrate binding interactions. Global bibliometric analysis (2012–2025) summarizes global research trends and collaborations in laccase-mediated bioremediation research. This combination of experimental literature and bibliometric analysis aims to provide a comprehensive overview of current research directions and technological potential of laccases. The review also identifies key challenges associated with enzyme operational stability, production, and scalability. Future research developments should focus on integrating protein engineering, nanobiocatalysis, and AI-assisted process optimization to enhance the efficiency and scalability of laccase-based industrial applications within the circular bioeconomic framework.