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<p>This study developed and characterized a novel antibacterial coating for polyvinyl chloride (PVC) tracheal tubes by depositing silver nanoparticles (AgNPs) onto a polydopamine (PDA) layer. The PDA coating successfully enhanced surface hydrophilicity, as confirmed by contact angle analysis. Characterization via UV-VIS, FTIR, FE-SEM, AFM, and XRD verified the successful synthesis and deposition of AgNPs with an average size of ~ 70–100&#xa0;nm and over 50% surface coverage. The antimicrobial efficacy of the PDA/AgNP-coated tubes was evaluated against six pathogens. Results demonstrated significant, time-dependent growth inhibition of <i>Candida albicans</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Staphylococcus aureus</i>. In contrast, <i>Acinetobacter baumannii</i> exhibited resistance. A key finding was the inverse relationship between the incubation time for AgNP deposition and antimicrobial efficacy, attributed to nanoparticle agglomeration. Furthermore, coatings stabilized at a lower ultrasonic power (150&#xa0;W) showed significantly greater antibacterial activity and stability than those treated at 300&#xa0;W, due to reduced nanoparticle detachment. This research confirms that PDA/AgNP-coated tracheal tubes are a promising strategy to reduce microbial colonization, with the optimization of deposition and stabilization parameters being crucial for maximizing their clinical potential.</p>

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Survey on the antibacterial effects of tracheal tubes coated with silver nanoparticles

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Reza Bahramabadi,
  • Hamid Hakimi,
  • Mohamad Zare-Bidaki,
  • Hassan Hashemipour Rafsanjani,
  • Fatemeh Jadidi,
  • Abolfazl Nasiri Rafsanjani,
  • Hasan Ebrahimi Shahmabadi

摘要

This study developed and characterized a novel antibacterial coating for polyvinyl chloride (PVC) tracheal tubes by depositing silver nanoparticles (AgNPs) onto a polydopamine (PDA) layer. The PDA coating successfully enhanced surface hydrophilicity, as confirmed by contact angle analysis. Characterization via UV-VIS, FTIR, FE-SEM, AFM, and XRD verified the successful synthesis and deposition of AgNPs with an average size of ~ 70–100 nm and over 50% surface coverage. The antimicrobial efficacy of the PDA/AgNP-coated tubes was evaluated against six pathogens. Results demonstrated significant, time-dependent growth inhibition of Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. In contrast, Acinetobacter baumannii exhibited resistance. A key finding was the inverse relationship between the incubation time for AgNP deposition and antimicrobial efficacy, attributed to nanoparticle agglomeration. Furthermore, coatings stabilized at a lower ultrasonic power (150 W) showed significantly greater antibacterial activity and stability than those treated at 300 W, due to reduced nanoparticle detachment. This research confirms that PDA/AgNP-coated tracheal tubes are a promising strategy to reduce microbial colonization, with the optimization of deposition and stabilization parameters being crucial for maximizing their clinical potential.