<p>Chemical inputs in agricultural fields as a pesticides or fertilizers, resulted in huge challenges for the environment, soil fertility, and unsafe agricultural products that increased risk of human health and environmental pollution. Here, we focused on the importance of actinomycetes in agricultural field. Actinomycetes a Gram-positive bacteria and have several functional roles to produce bioactive compounds such as biocontrol agents, biofertilizers, and biopesticides. Due to the overloading demand of food and the emergence of new plant pathogens, the current agriculture practices often heavily rely on chemical fertilizers and pesticides. Therefore, actinomycetes could play a significant role as Plant Growth-Promoting Microorganisms (PGPM) that ability to fix N₂, produce ACC deaminase, siderophore, IAA, solubilize potassium and phosphorus, as well as HCN and several antibiotic productions, which helps to reduce the use of agrochemicals (chemical fertilizers and pesticides). These PGPMs can provide environment friendly solutions for crop protection and improvement. Beyond agriculture, actinomycetes also have the ability to synthesize an array of metabolites that suppress plant pathogens, promote plant growth, and contribute to the soil health, making them valuable in sustainable farming practices. Commercially, actinomycete-based formulations are increasingly utilization in vegetable production and other agricultural systems as substitutes for synthetic inputs. Many studies published on actinomycetes that highlighted their role in synthesizing pharmaceutically relevant compounds such as antibiotics, antifungal and anti-cancerous compounds for large-scale industrial applications. In this review, we tried to summarize the functional attributes of actinomycetes for industrial as well as agriculture applications.</p>